Diet Protocol
Energy deficit with elevated protein intake and whole-food meal structure.[1938,2747,3152, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
64/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Best fit: Fat loss with lean mass retention..[1092,1216,1938, etc.]
Goal alignment: Body Composition, Performance, Metabolic Health.[1092,1216,1938, etc.]
Protocol Type
Diet Plan
Evidence Tier
HIGH
Best Fit
Fat loss with lean mass retention.
Primary Focus
Body Composition, Performance
Clinical Depth
Humans: 246 • RCTs: 115 • Meta: 12
Cohort / Real-World
Cohort signals: 23
Safety Markers
Adverse signals: 25 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
246 total studies · 5 recent
Timeline
Total indexed
246
Human studies
246
Randomized trials
115
Safety adverse signals
25
Cohort signals
23
Adherence/dropout signals
19
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when large human trial/meta/cohort volume exists for the named dietary protocol.
Total indexed
246
Human studies
246
Randomized trials
115
Safety adverse signals
25
Cohort signals
23
Adherence/dropout signals
19
Meta-analyses
12
Mechanistic signals
8
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39631998 • 2024 Dec
Effects of high-protein supplementation during cancer therapy: a systematic review and meta-analysis.
Am J Clin Nutr
Open PubMedPMID 38424054 • 2024 Feb 29
Effects of high-protein diets on the cardiometabolic factors and reproductive hormones of women with polycystic ovary syndrome: a systematic review and meta-analysis.
Nutr Diabetes
Open PubMedPMID 30431586 • 2018 Nov
High protein diet is of benefit for patients with type 2 diabetes: An updated meta-analysis.
Medicine (Baltimore)
Open PubMedPMID 31466731 • 2020 Jun
Effects of high-protein diet on glycemic control, insulin resistance and blood pressure in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr
Open PubMedPMID 35488636 • 2022 May 2
[Effects of high protein diet on anthropometric indices and blood lipid in overweight and obese children: a Meta-analysis].
Zhonghua Er Ke Za Zhi
Open PubMedPMID 33938779 • 2022
Efficacy and safety of a specific commercial high-protein meal-replacement product line in weight management: meta-analysis of randomized controlled trials.
Crit Rev Food Sci Nutr
Open PubMedPMID 28166780 • 2017 Feb 6
Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial.
Nutr J
Open PubMedPMID 40336033 • 2025 May 7
Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial.
BMC Med
Open PubMedPMID 37621140 • 2023 Jan-Dec
The Effect of Mediterranean Diet on Body Composition, Inflammatory Factors, and Nutritional Status in Patients with Cachexia Induced by Colorectal Cancer: A Randomized Clinical Trial.
Integr Cancer Ther
Open PubMedPMID 34993571 • 2022 Mar
Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial.
Diabetologia
Open PubMedPMID 39232439 • 2024 Oct
Analysis of combinatory effects of free weight resistance training and a high-protein diet on body composition and strength capacity in postmenopausal women - A 12-week randomized controlled trial.
J Nutr Health Aging
Open PubMedPMID 33096810 • 2020 Oct 21
A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.
Nutrients
Open PubMedPMID 32827096 • 2020 Sep
Protein, amino acids and obesity treatment.
Rev Endocr Metab Disord
Open PubMedPMID 19818279 • 2009 Nov-Dec
High-protein diet promotes a moderate postpartum weight loss in a prospective cohort of Brazilian women.
Nutrition
Open PubMedPMID 31451269 • 2019 Oct
Effect of diet composition on insulin sensitivity in humans.
Clin Nutr ESPEN
Open PubMedPMID 40829826 • 2025 Aug 18
Consequences of weight cycling in patients with obesity and the potential impact of high protein diet: a health economic assessment from a US societal perspective.
BMJ Open
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Human diet protocol literature
Counts from structured PubMed protocol-specific query set.
Outcome: Humans 246, RCT 115, meta 12, cohort 23.[1938,2747,3152, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39631998 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38424054 from Nutr Diabetes.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30431586 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31466731 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35488636 from Zhonghua Er Ke Za Zhi.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33938779 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28166780 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40336033 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37621140 from Integr Cancer Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34993571 from Diabetologia.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39232439 from J Nutr Health Aging.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33096810 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32827096 from Rev Endocr Metab Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19818279 from Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31451269 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40829826 from BMJ Open.
Outcome: See linked PubMed abstract for methods and outcomes.[1938,2747,3152, etc.]
Open source