Food
Vitamin C and flavanones support antioxidant and endothelial pathways.[2419,2575,2762, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-10
Mixed / Neutral • confidence Moderate
Safety Friction
82/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 6 • links 25
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Classification: prioritize.[452,1185,2419, etc.]
Best fit: Users with low fruit intake and poor produce diversity..[452,1185,2419, etc.]
Goal alignment: Immune Support, Heart Health, Skin Hair.[452,1185,2419, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
Users with low fruit intake and poor produce diversity.
Primary Focus
Immune Support, Heart Health
Clinical Depth
Humans: 1,274 • RCTs: 168 • Meta: 28
Cohort / Real-World
Cohort signals: 182
Safety Markers
Adverse signals: 64 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
1274 total studies · 4 recent
Timeline
Total indexed
1,274
Human studies
1,274
Cohort signals
182
Randomized trials
168
In vitro / tissue
97
Safety adverse signals
64
Weighted direction score: -10 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
1,274
Human studies
1,274
Cohort signals
182
Randomized trials
168
In vitro / tissue
97
Safety adverse signals
64
Meta-analyses
28
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 28338764 • 2017 Jun 1
Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies.
Int J Epidemiol
Open PubMedPMID 32006369 • 2020
Food Color and Autism: A Meta-Analysis.
Adv Neurobiol
Open PubMedPMID 26778708 • 2016 Aug
Consumption of citrus and cruciferous vegetables with incident type 2 diabetes mellitus based on a meta-analysis of prospective study.
Prim Care Diabetes
Benefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 3
Signal confidence: 0.47
Benefits
Adverse
No Effect
Community confidence 0.47 with mentions: benefit 1, adverse 1, no-effect 0.
Subreddit coverage: carnivorediet, nutrition, vegan.
post • r/vegan • adverse
The best dietary plan to get full nutrients from vegan food that I could personally find Starting, I want to point out that I'm NOT a professional, and this is just my personal research to find the least supplement-dependent diet. another …
Open mentionpost • r/vegan • unclear
Is it possible for me to be vegan with my allergies? I have always felt that it wasn’t possible for me to go vegan because of my allergies. I realize I don’t actually know for sure, I’ve just assumed. Here is my list of allergies. Are ther…
Open mentionpost • r/nutrition • benefit
I’ve listed 35 polyphenols below. In nutrition, is there a 'Goldilocks zone' for these? I'm curious if the science shows a point where taking more actually stops being helpful and becomes 'too much. 1. **Black Elderberries** 2. **Blackcurr…
Evidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 1274, RCT 168, meta 28, cohort 182.[2419,2575,2762, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28338764 from Int J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.
Composite of study volume, RCTs, and meta-analyses
PMID 33529754 • 2021 Apr
Citrus fruit intake and lung cancer risk: A meta-analysis of observational studies.
Pharmacol Res
Open PubMedPMID 33000670 • 2020 Oct 20
Relation of Different Fruit and Vegetable Sources With Incident Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.
J Am Heart Assoc
Open PubMedPMID 36658686 • 2024 Apr
Citrus fruit intake and incidence of renal cell carcinoma: A meta-analysis of observational studies.
Asia Pac J Clin Oncol
Open PubMedPMID 38732578 • 2024 Apr 28
Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial.
Nutrients
Open PubMedPMID 33808180 • 2021 Mar 30
Twelve-Week Mediterranean Diet Intervention Increases Citrus Bioflavonoid Levels and Reduces Inflammation in People with Type 2 Diabetes Mellitus.
Nutrients
Open PubMedPMID 36615801 • 2022 Dec 28
Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial.
Nutrients
Open PubMedPMID 35276783 • 2022 Jan 18
Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study.
Nutrients
Open PubMedPMID 25588369 • 2015
Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management.
Nat Prod Res
Open PubMedPMID 39339791 • 2024 Sep 20
Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial.
Nutrients
Open PubMedPMID 31906271 • 2020 Jan 1
Fruit and Vegetable Intake and Mental Health in Adults: A Systematic Review.
Nutrients
Open PubMedPMID 39543781 • 2024 Nov 14
F. prausnitzii potentially modulates the association between citrus intake and depression.
Microbiome
Open PubMedPMID 37247693 • 2023 Aug
Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease.
Pharmacol Ther
Open PubMedPMID 36906146 • 2023 May
Kidney Stone Prevention.
Adv Nutr
Open PubMedpost • r/carnivorediet • unclear
Carnivore struggles I’m not sure if this is the correct place to write this post but I’m a bit desperate. Long story short I was diagnosed with RA (rheumatoid arthritis) in 2022, alongside with osteoporosis, and now finding out that I pote…
Open mentionpost • r/carnivorediet • unclear
How do you not get Survey? Store, who spent months at sea and ate only salted pork would eventually get scurvy, which came from a lack of citrus fruits. I’m genuinely curious … if all you eat is meat, it seems like you’re missing out on so…
Open mentionCommunity Sources
PUBMED • 2020 • Human evidence curation set
PMID 32006369 from Adv Neurobiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26778708 from Prim Care Diabetes.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33529754 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33000670 from J Am Heart Assoc.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 36658686 from Asia Pac J Clin Oncol.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38732578 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33808180 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36615801 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35276783 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25588369 from Nat Prod Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39339791 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31906271 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39543781 from Microbiome.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37247693 from Pharmacol Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36906146 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2419,2575,2762, etc.]
Open source