Food
Coffee bioactives and caffeine are linked to cognitive and cardiometabolic outcomes in many cohorts.[2242,2716,2894, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
73/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
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Classification: case-dependent.[1072,1187,2242, etc.]
Best fit: Users tolerating caffeine and avoiding late-day intake..[1072,1187,2242, etc.]
Goal alignment: Cognitive, Energy, Longevity.[1072,1187,2242, etc.]
Classification
Case Dependent
Evidence Tier
HIGH
Best Fit
Users tolerating caffeine and avoiding late-day intake.
Primary Focus
Cognitive, Energy
Clinical Depth
Humans: 2,618 • RCTs: 127 • Meta: 236
Cohort / Real-World
Cohort signals: 815
Safety Markers
Adverse signals: 41 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
2618 total studies · 5 recent
Timeline
Total indexed
2,618
Human studies
2,618
Cohort signals
815
Meta-analyses
236
Randomized trials
127
In vitro / tissue
71
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
2,618
Human studies
2,618
Cohort signals
815
Meta-analyses
236
Randomized trials
127
In vitro / tissue
71
Safety adverse signals
41
Animal-only studies
0
Distribution of evidence by study design strength
Evidence Strength: High
PMID 29167102 • 2017 Nov 22
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes.
BMJ
Open PubMedPMID 37447390 • 2023 Jul 7
Coffee Consumption and Risk of Hypertension in Adults: Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 31055709 • 2019 Aug
Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers.
Eur J Epidemiol
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22coffee%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 2618, RCT 127, meta 236, cohort 815.[2242,2716,2894, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 29167102 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,, etc.]
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
Composite of study volume, RCTs, and meta-analyses
PMID 34690004 • 2022 Jan
Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study.
Am J Kidney Dis
Open PubMedPMID 24201300 • 2014 Feb 11
Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies.
Circulation
Open PubMedPMID 33418132 • 2022 Mar
Obesity, Type 2 Diabetes, Lifestyle Factors, and Risk of Gallstone Disease: A Mendelian Randomization Investigation.
Clin Gastroenterol Hepatol
Open PubMedPMID 41206802 • 2026 Jan 27
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial.
JAMA
Open PubMedPMID 36947466 • 2023 Mar 23
Acute Effects of Coffee Consumption on Health among Ambulatory Adults.
N Engl J Med
Open PubMedPMID 35639365 • 2023 Mar
Effect of Coffee and Tea Consumption on Adolescent Weight Control: An Interventional Pilot Study.
Child Obes
Open PubMedPMID 38308805 • 2024 Jan
Acute Effects of Coffee Consumption on Blood Pressure and Endothelial Function in Individuals with Hypertension on Antihypertensive Drug Treatment: A Randomized Crossover Trial.
High Blood Press Cardiovasc Prev
Open PubMedPMID 27858150 • 2018 Mar
Coffee and oxidative stress: a human intervention study.
Eur J Nutr
Open PubMedPMID 34564706 • 2022 Jan
CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.
Int J Obes (Lond)
Open PubMedPMID 38963648 • 2024 Dec
Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.
Geroscience
Open PubMedPMID 29474816 • 2018 May-Jun
Coffee for Cardioprotection and Longevity.
Prog Cardiovasc Dis
Open PubMedPMID 39266809 • 2025 Apr
Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.
Geroscience
Open PubMedPMID 40626862 • 2025 Sep 22
Coffee and cardiovascular disease.
Eur Heart J
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=coffee
Community Sources
PUBMED • 2023 • Human evidence curation set
PMID 37447390 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31055709 from Eur J Epidemiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34690004 from Am J Kidney Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24201300 from Circulation.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33418132 from Clin Gastroenterol Hepatol.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41206802 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36947466 from N Engl J Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35639365 from Child Obes.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38308805 from High Blood Press Cardiovasc Prev.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 27858150 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34564706 from Int J Obes (Lond).
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38963648 from Geroscience.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29474816 from Prog Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39266809 from Geroscience.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40626862 from Eur Heart J.
Outcome: See linked PubMed abstract for methods and outcomes.[2242,2716,2894, etc.]
Open source