Food
Provides EPA/DHA, protein, and micronutrients linked to cardiometabolic and cognitive outcomes.[2075,2103,2262, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-28
Caution Lean • confidence Moderate
Safety Friction
47/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 15 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Classification: prioritize.[388,1200,2075, etc.]
Best fit: People with low omega-3 intake or high triglycerides..[388,1200,2075, etc.]
Goal alignment: Heart Health, Brain Health, Longevity.[388,1200,2075, etc.]
Classification
Prioritize
Evidence Tier
HIGH
Best Fit
People with low omega-3 intake or high triglycerides.
Primary Focus
Heart Health, Brain Health
Clinical Depth
Humans: 529 • RCTs: 88 • Meta: 9
Cohort / Real-World
Cohort signals: 152
Safety Markers
Adverse signals: 10 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
624 total studies
Timeline
Total indexed
624
Human studies
529
Cohort signals
152
Randomized trials
88
Animal-only studies
30
In vitro / tissue
15
Weighted direction score: -28 (Caution Lean)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
624
Human studies
529
Cohort signals
152
Randomized trials
88
Animal-only studies
30
In vitro / tissue
15
Safety adverse signals
10
Meta-analyses
9
Distribution of evidence by study design strength
Evidence Strength: High
PMID 35108375 • 2022 Oct 2
Relations between the Consumption of Fatty or Lean Fish and Risk of Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis.
Adv Nutr
Open PubMedPMID 24828061 • 2014 May
ALA, fatty fish or marine n-3 fatty acids for preventing DM?: a systematic review and meta-analysis.
Curr Diabetes Rev
Open PubMedPMID 37960192 • 2023 Oct 26
Fish Intake in Relation to Fatal and Non-Fatal Cardiovascular Risk: A Systematic Review and Meta-Analysis of Cohort Studies.
Benefit reports: 4
Adverse reports: 7
No-effect reports: 0
Mixed reports: 3
Unclear reports: 1
Signal confidence: 0.60
Benefits
Adverse
No Effect
Community confidence 0.60 with mentions: benefit 1, adverse 1, no-effect 0.
Subreddit coverage: Biohackers, carnivorediet, nutrition.
post • r/carnivorediet • unclear
This report examines the evidence and debates surrounding the hypothesis that early human ancestors were primarily facultative carnivores—hunting large, fatty megafauna and fatty fish—to secure the high-energy, fat‐rich diets that may have…
Open mentionpost • r/nutrition • benefit
For those who are taking omega 3, what difference did it make for you? Hello everyone. I am working on improving my overall nutrition and I keep seeing omega 3 mentioned as an essential part of a healthy diet. I try to eat fatty fish once …
Open mentionpost • r/carnivorediet • adverse
Low libido after 3 years on the Carnivore Diet Hi everyone, I've been following the carnivore diet since 2022, and I've managed to resolve more than 15 different health issues, including sleep apnea, eczema, seasonal allergies, arthritis i…
Evidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 529, RCT 88, meta 9, cohort 152.[2075,2103,2262, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35108375 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.
Composite of study volume, RCTs, and meta-analyses
Nutrients
PMID 30470232 • 2018 Nov 23
Effects of fatty and lean fish intake on stroke risk: a meta-analysis of prospective cohort studies.
Lipids Health Dis
Open PubMedPMID 29524247 • 2018 Jun
The role of fish intake on asthma in children: A meta-analysis of observational studies.
Pediatr Allergy Immunol
Open PubMedPMID 33917229 • 2021 Apr 7
Heterogeneity of Associations between Total and Types of Fish Intake and the Incidence of Type 2 Diabetes: Federated Meta-Analysis of 28 Prospective Studies Including 956,122 Participants.
Nutrients
Open PubMedPMID 37156666 • 2023 Jul
Fatty fish consumption reduces lipophilic index in erythrocyte membranes and serum phospholipids.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 33978160 • 2021 Aug 7
Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children.
J Nutr
Open PubMedPMID 32008913 • 2020 Mar 9
Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 34548243 • 2021 Sep-Oct
Lipidomic changes of LDL after consumption of Camelina sativa oil, fatty fish and lean fish in subjects with impaired glucose metabolism-A randomized controlled trial.
J Clin Lipidol
Open PubMedPMID 25527657 • 2015 Jan
Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial.
J Nutr
Open PubMedPMID 32918853 • 2020 Oct
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
Mol Nutr Food Res
Open PubMedPMID 34684583 • 2021 Oct 13
Evidence Update on the Relationship between Diet and the Most Common Cancers from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: A Systematic Review.
Nutrients
Open PubMedPMID 22051327 • 2011 Nov 8
Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.
J Am Coll Cardiol
Open PubMedPMID 22499449 • 2012 Apr
Nutrition and vascular dementia.
J Nutr Health Aging
Open PubMedPMID 24383511 • 2014 Jan
Le statut en acide eicosapentaénoïque est associé à des valeurs plus élevées de l'indice calcanéen ultrasonore stiffness chez les femmes autochtones: résultats d'une étude longitudinale et de deux études transversales.
Appl Physiol Nutr Metab
Open PubMedpost • r/Biohackers • mixed
Ditching the Omega 3 Capsules: Why I Eat Fatty Fish Instead of Taking Supplements. Hey everyone, Today I read another omega-3 thread here and ended up revisiting my own relationship with fish/algae oil. I’m generally skeptical of isolated …
Open mentionpost • r/Biohackers • mixed
My 30-day experiment with “brain-supporting” foods (what actually changed, what didn’t) I wanted to share this in case it helps anyone else who’s dealing with brain fog, low energy, or bad sleep. For the past 30 days I intentionally change…
Open mentionpost • r/carnivorediet • mixed
I’m 2 weeks and 2 days into this Carnivore Diet and let me tell you… First let me describe the Carnivore Diet I am following the last few weeks since I started: strict carnivore diet (meat, eggs, butter from grass fed cows) and I cheated f…
Open mentionCommunity Sources
PUBMED • 2014 • Human evidence curation set
PMID 24828061 from Curr Diabetes Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37960192 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30470232 from Lipids Health Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29524247 from Pediatr Allergy Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33917229 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37156666 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33978160 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32008913 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34548243 from J Clin Lipidol.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25527657 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32918853 from Mol Nutr Food Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34684583 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 22051327 from J Am Coll Cardiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22499449 from J Nutr Health Aging.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24383511 from Appl Physiol Nutr Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2075,2103,2262, etc.]
Open source