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Food

Maltodextrin

Rapidly digestible starch additive can contribute to glycemic spikes in low-fiber products.[1889,2884,3110, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence
Metabolic HealthGut HealthBody Composition

Composite Rating

4.0/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

0

Mixed / Neutral • confidence Minimal

Safety Friction

69/100

Moderate signal from adverse/interaction markers

Data Completeness

100%

Studies 16 • mentions 0 • links 25

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Classification: limit.[1107,1241,1889, etc.]

Best fit: Users with glucose-control goals or high ultra-processed food intake..[1107,1241,1889, etc.]

Goal alignment: Metabolic Health, Gut Health, Body Composition.[1107,1241,1889, etc.]

Classification

Limit

Evidence Tier

HIGH

Best Fit

Users with glucose-control goals or high ultra-processed food intake.

Primary Focus

Metabolic Health, Gut Health

Safety and Pitfalls

  • Often co-occurs with low-fiber processed foods.

At-A-Glance Evidence Architecture[1889,2884,3110, etc.]

Clinical Depth

Humans: 674 • RCTs: 439 • Meta: 4

Cohort / Real-World

Cohort signals: 54

Safety Markers

Adverse signals: 34 • Interactions: 0

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

674 total studies · 8 recent

Timeline

20092025

Top Signal Metrics[1889,2884,3110, etc.]

Total indexed

674

Human studies

674

Randomized trials

439

In vitro / tissue

137

Cohort signals

54

Safety adverse signals

34

Community Direction Mix[1107,1241,6267]

Weighted direction score: 0 (Mixed / Neutral)

Benefit0

Evidence Quality Summary[1889,2884,3110, etc.]

High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.

Total indexed

674

Human studies

674

Randomized trials

439

In vitro / tissue

137

Cohort signals

54

Safety adverse signals

34

Meta-analyses

4

Animal-only studies

0

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a4
Randomized TrialsLevel 1b439
Cohort StudiesLevel 2b54
Human Studies (other)Level 3-4177
All IndexedAll levels674
100

Evidence Strength: High

Top Human Studies[1889,2884,3110, etc.]

PMID 36178302 • 2024

Synergy of carbohydrate and caffeine ingestion on physical performance and metabolic responses to exercise: A systematic review with meta-analysis.

Crit Rev Food Sci Nutr

Open PubMed

PMID 33187278 • 2020 Nov 11

The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Nutrients

Open PubMed

PMID 19126874 • 2009 Jan

Community Report Frequency[1107,1241,6267]

Benefit reports: 0

Adverse reports: 0

No-effect reports: 0

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[1107,1241,6267]

Benefits

  • Metabolic Health: 1
  • Gut Health: 1
  • Body Composition: 1

Adverse

  • Often co-occurs with low-fiber processed foods: 1

No Effect

  • insufficient no-effect reports captured: 0

Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.

Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22maltodextrin%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)

Community Evidence Examples[1107,1241,6267]

aggregate • unclear

No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.

Open mention

Primary Source Links

Evidence Sources

  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22maltodextrin%22%20AND%20humans%5BMeSH%20Terms%5D)%20AND%20(diet*%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20consumption%5BTitle%2FAbstract%5D%20OR%20feeding%5BTitle%2FAbstract%5D%20OR%20nutrition%5BTitle%2FAbstract%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22maltodextrin%22%20AND%20humans%5BMeSH%20Terms%5D)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(diet*%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20consumption%5BTitle%2FAbstract%5D%20OR%20feeding%5BTitle%2FAbstract%5D%20OR%20nutrition%5BTitle%2FAbstract%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22maltodextrin%22%20AND%20humans%5BMeSH%20Terms%5D)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(diet*%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20consumption%5BTitle%2FAbstract%5D%20OR%20feeding%5BTitle%2FAbstract%5D%20OR%20nutrition%5BTitle%2FAbstract%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D

Scientific Evidence Notes[1889,2884,3110, etc.]

1. PubMed triage evidence summary: Maltodextrin

PUBMED • Humans + preclinical triage

Counts from structured PubMed query set for diet/intake context.

Outcome: Humans 674, RCT 439, meta 4, cohort 54.[1889,2884,3110, etc.]

Open source
2. Synergy of carbohydrate and caffeine ingestion on physical performance and metabolic responses to exercise: A systematic review with meta-analysis.

PUBMED • 2024 • Human evidence curation set

PMID 36178302 from Crit Rev Food Sci Nutr.

Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]

[1107,1241,1889, etc.]
Adverse0
No Effect0
Mixed0

No directional mention volume was resolved; fallback profile metadata is shown in other sections.

Composite of study volume, RCTs, and meta-analyses

Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): meta-analysis of randomized controlled trials.

Am J Clin Nutr

Open PubMed

PMID 41199504 • 2025 Dec

Fed, not fasted: is carbohydrate mouth rinsing still ergogenic? A three-level meta-analysis.

J Int Soc Sports Nutr

Open PubMed

PMID 37078654 • 2023 Jan-Dec

Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.

Gut Microbes

Open PubMed

PMID 40265319 • 2025 Sep

Does creatine cause hair loss? A 12-week randomized controlled trial.

J Int Soc Sports Nutr

Open PubMed

PMID 39356506 • 2024 Oct 1

Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial.

JAMA Netw Open

Open PubMed

PMID 29117309 • 2018 Jan 1

Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.

JAMA Dermatol

Open PubMed

PMID 30262813 • 2019 Sep

Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial.

Int J Obes (Lond)

Open PubMed

PMID 32440730 • 2020 Oct

Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.

Eur J Nutr

Open PubMed

PMID 36216216 • 2023 Jan 1

Effects of the maize-derived protein zein, and the milk proteins casein, whey, and α-lactalbumin, on subjective measures of satiety and food intake in normal-weight young men.

Appetite

Open PubMed

PMID 37620294 • 2024 Jun 20

Safety of high-carbohydrate fluid diet 2 h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography: A single-blind, multicenter, randomized controlled trial.

Chin Med J (Engl)

Open PubMed

PMID 38448413 • 2024 Mar 6

Effect of inulin on breath hydrogen, postprandial glycemia, gut hormone release, and appetite perception in RYGB patients: a prospective, randomized, cross-over pilot study.

Nutr Diabetes

Open PubMed

PMID 38610034 • 2024 Apr 12

Probiotic supplementation and risk of necrotizing enterocolitis and mortality among extremely preterm infants-the Probiotics in Extreme Prematurity in Scandinavia (PEPS) trial: study protocol for a multicenter, double-blinded, placebo-controlled, and registry-based randomized controlled trial.

Trials

Open PubMed

PMID 41470798 • 2025 Dec 10

Ultra-Processed Foods and Inflammatory Bowel Disease: A Narrative Review of Epidemiology, Mechanisms, and Dietary Implications.

Nutrients

Open PubMed

PMID 33302879 • 2020 Dec 10

Exercise and Nutrition for Healthy AgeiNg (ENHANce) project - effects and mechanisms of action of combined anabolic interventions to improve physical functioning in sarcopenic older adults: study protocol of a triple blinded, randomized controlled trial.

BMC Geriatr

Open PubMed

Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=maltodextrin

  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22maltodextrin%22%20AND%20humans%5BMeSH%20Terms%5D)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(diet*%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20consumption%5BTitle%2FAbstract%5D%20OR%20feeding%5BTitle%2FAbstract%5D%20OR%20nutrition%5BTitle%2FAbstract%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22maltodextrin%22%20AND%20humans%5BMeSH%20Terms%5D)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(diet*%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20consumption%5BTitle%2FAbstract%5D%20OR%20feeding%5BTitle%2FAbstract%5D%20OR%20nutrition%5BTitle%2FAbstract%5D)%20AND%20(cohort%5BTitle%2FAbstract%5D%20OR%20prospective%5BTitle%2FAbstract%5D%20OR%20longitudinal%5BTitle%2FAbstract%5D)
  • https://pubmed.ncbi.nlm.nih.gov/36178302/
  • https://pubmed.ncbi.nlm.nih.gov/33187278/
  • https://pubmed.ncbi.nlm.nih.gov/19126874/
  • https://pubmed.ncbi.nlm.nih.gov/41199504/
  • https://pubmed.ncbi.nlm.nih.gov/37078654/
  • https://pubmed.ncbi.nlm.nih.gov/40265319/
  • https://pubmed.ncbi.nlm.nih.gov/39356506/
  • https://pubmed.ncbi.nlm.nih.gov/29117309/
  • https://pubmed.ncbi.nlm.nih.gov/30262813/
  • https://pubmed.ncbi.nlm.nih.gov/32440730/
  • https://pubmed.ncbi.nlm.nih.gov/36216216/
  • https://pubmed.ncbi.nlm.nih.gov/37620294/
  • https://pubmed.ncbi.nlm.nih.gov/38448413/
  • https://pubmed.ncbi.nlm.nih.gov/38610034/
  • https://pubmed.ncbi.nlm.nih.gov/41470798/
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22maltodextrin%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=maltodextrin
    • https://www.reddit.com/search/?q=Maltodextrin
    1889,
    2884,
    3110
    Open source
    3. The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    PUBMED • 2020 • Human evidence curation set

    PMID 33187278 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    4. Interventions to lower the glycemic response to carbohydrate foods with a low-viscosity fiber (resistant maltodextrin): meta-analysis of randomized controlled trials.

    PUBMED • 2009 • Human evidence curation set

    PMID 19126874 from Am J Clin Nutr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    5. Fed, not fasted: is carbohydrate mouth rinsing still ergogenic? A three-level meta-analysis.

    PUBMED • 2025 • Human evidence curation set

    PMID 41199504 from J Int Soc Sports Nutr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    6. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.

    PUBMED • 2023 • Human evidence curation set

    PMID 37078654 from Gut Microbes.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    7. Does creatine cause hair loss? A 12-week randomized controlled trial.

    PUBMED • 2025 • Human evidence curation set

    PMID 40265319 from J Int Soc Sports Nutr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    8. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial.

    PUBMED • 2024 • Human evidence curation set

    PMID 39356506 from JAMA Netw Open.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    9. Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.

    PUBMED • 2018 • Human evidence curation set

    PMID 29117309 from JAMA Dermatol.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    10. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial.

    PUBMED • 2019 • Human evidence curation set

    PMID 30262813 from Int J Obes (Lond).

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    11. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.

    PUBMED • 2020 • Human evidence curation set

    PMID 32440730 from Eur J Nutr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    12. Effects of the maize-derived protein zein, and the milk proteins casein, whey, and α-lactalbumin, on subjective measures of satiety and food intake in normal-weight young men.

    PUBMED • 2023 • Human evidence curation set

    PMID 36216216 from Appetite.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    13. Safety of high-carbohydrate fluid diet 2 h versus overnight fasting before non-emergency endoscopic retrograde cholangiopancreatography: A single-blind, multicenter, randomized controlled trial.

    PUBMED • 2024 • Human evidence curation set

    PMID 37620294 from Chin Med J (Engl).

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    14. Effect of inulin on breath hydrogen, postprandial glycemia, gut hormone release, and appetite perception in RYGB patients: a prospective, randomized, cross-over pilot study.

    PUBMED • 2024 • Human evidence curation set

    PMID 38448413 from Nutr Diabetes.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    15. Probiotic supplementation and risk of necrotizing enterocolitis and mortality among extremely preterm infants-the Probiotics in Extreme Prematurity in Scandinavia (PEPS) trial: study protocol for a multicenter, double-blinded, placebo-controlled, and registry-based randomized controlled trial.

    PUBMED • 2024 • Human evidence curation set

    PMID 38610034 from Trials.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    16. Ultra-Processed Foods and Inflammatory Bowel Disease: A Narrative Review of Epidemiology, Mechanisms, and Dietary Implications.

    PUBMED • 2025 • Human evidence curation set

    PMID 41470798 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source
    17. Exercise and Nutrition for Healthy AgeiNg (ENHANce) project - effects and mechanisms of action of combined anabolic interventions to improve physical functioning in sarcopenic older adults: study protocol of a triple blinded, randomized controlled trial.

    PUBMED • 2020 • Human evidence curation set

    PMID 33302879 from BMC Geriatr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1889,2884,3110, etc.]

    Open source