Food
High omega-6 refined oils are often delivered alongside ultra-processed, high-calorie food matrices.[1407,1437,1553, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
75/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
14/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 16 • mentions 0 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Classification: limit.[1126,1273,1407, etc.]
Best fit: Users with high fast-food or packaged-snack intake..[1126,1273,1407, etc.]
Goal alignment: Metabolic Health, Recovery, Heart Health.[1126,1273,1407, etc.]
Classification
Limit
Evidence Tier
HIGH
Best Fit
Users with high fast-food or packaged-snack intake.
Primary Focus
Metabolic Health, Recovery
Clinical Depth
Humans: 55 • RCTs: 5 • Meta: 0
Cohort / Real-World
Cohort signals: 7
Safety Markers
Adverse signals: 1 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
55 total studies · 3 recent
Timeline
Total indexed
55
Human studies
55
Cohort signals
7
Randomized trials
5
In vitro / tissue
1
Safety adverse signals
1
Weighted direction score: 0 (Mixed / Neutral)
High when there are >=2 human meta-analyses, or strong human trial/cohort volume with substantial human literature.
Total indexed
55
Human studies
55
Cohort signals
7
Randomized trials
5
In vitro / tissue
1
Safety adverse signals
1
Animal-only studies
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35381848 • 2022 Sep
No evidence of differential impact of sunflower and rapeseed oil on biomarkers of coronary artery disease or chronic kidney disease in healthy adults with overweight and obesity: result from a randomised control trial.
Eur J Nutr
Open PubMedPMID 33188423 • 2020 Dec 10
Two Blends of Refined Rice Bran, Flaxseed, and Sesame Seed Oils Affect the Blood Lipid Profile of Chinese Adults with Borderline Hypercholesterolemia to a Similar Extent as Refined Olive Oil.
J Nutr
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=8&q=%22seed%20oils%22%20(diet%20OR%20nutrition%20OR%20meals%20OR%20side%20effects%20OR%20experience%20OR%20results)%20(subreddit%3Anutrition%20OR%20subreddit%3AScientificNutrition%20OR%20subreddit%3Aloseit%20OR%20subreddit%3AMealPrepSunday%20OR%20subreddit%3Aketo%20OR%20subreddit%3Afasting%20OR%20subreddit%3Amediterraneandiet%20OR%20subreddit%3Avegan%20OR%20subreddit%3Avegetarian%20OR%20subreddit%3Acarnivorediet%20OR%20subreddit%3Abiohackers%20OR%20subreddit%3Alongevity)
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
PUBMED • Humans + preclinical triage
Counts from structured PubMed query set for diet/intake context.
Outcome: Humans 55, RCT 5, meta 0, cohort 7.[1407,1437,1553, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35381848 from Eur J Nutr.
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
PMID 8400591 • 1993 Jul-Aug
Soybean oil, blackcurrant seed oil, medium-chain triglycerides, and plasma phospholipid fatty acids of stressed patients.
Nutrition
PMID 11237929 • 2001 Mar
Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y.
Am J Clin Nutr
Open PubMedPMID 11435508 • 2001 Jul
Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans.
J Nutr
Open PubMedPMID 41461015 • 2026 Mar 1
Cardiometabolic benefits of replacing saturated fatty acids with unsaturated fatty acids.
Curr Opin Clin Nutr Metab Care
Open PubMedPMID 18205988 • 2008 Oct
Diet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort (European Prospective Investigation into Cancer and Nutrition).
Public Health Nutr
Open PubMedPMID 14870827 • 2003 Nov-Dec
Relationship between plasma fatty acid composition and diet over previous years in the Italian centers of the European Prospective Investigation into Cancer and Nutrition (EPIC).
Tumori
Open PubMedPMID 18952225 • 2009 May
Dietary lipids and geriatric depression scale score among elders: the EPIC-Greece cohort.
J Psychiatr Res
Open PubMedPMID 14576750 • 2003 Nov
Tracing the Mediterranean diet through principal components and cluster analyses in the Greek population.
Eur J Clin Nutr
Open PubMedPMID 33499027 • 2021 Jan 22
COVID-19-Related Quarantine Effect on Dietary Habits in a Northern Italian Rural Population: Data from the Brisighella Heart Study.
Nutrients
Open PubMedPMID 39475012 • 2024 Oct 28
Perspective on the health effects of unsaturated fatty acids and commonly consumed plant oils high in unsaturated fat.
Br J Nutr
Open PubMedPMID 39820582 • 2025 Jul 1
Are Seed Oils the Culprit in Cardiometabolic and Chronic Diseases? A Narrative Review.
Nutr Rev
Open PubMedPMID 37513547 • 2023 Jul 13
Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease.
Nutrients
Open PubMedPMID 34658440 • 2021 Sep-Oct
The Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing the Risk of Autoimmune Diseases, Asthma, and Allergies.
Mo Med
Open PubMedPMID 31353657 • 2019 Feb
A potential new source: Nutritional and antioxidant properties of edible oils from cucurbit seeds and their impact on human health.
J Food Biochem
Open PubMedFallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=seed%20oils
Community Sources
PUBMED • 2020 • Human evidence curation set
PMID 33188423 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 1993 • Human evidence curation set
PMID 8400591 from Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11237929 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11435508 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41461015 from Curr Opin Clin Nutr Metab Care.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18205988 from Public Health Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 14870827 from Tumori.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 18952225 from J Psychiatr Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 14576750 from Eur J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33499027 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39475012 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39820582 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37513547 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34658440 from Mo Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31353657 from J Food Biochem.
Outcome: See linked PubMed abstract for methods and outcomes.[1407,1437,1553, etc.]
Open source