Supplement
Supports broad cellular function with category-specific mechanisms.[1351,1895,3062, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
96/100
High depth from human/RCT/meta counts
Community Direction
21
Positive Lean • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 10 • mentions 10 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[77,417,445, etc.]
Dose guide: Human-study daily dose: 4.49 mg/day (early-confidence extraction from PubMed abstracts)..[77,417,445, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 4.49 mg/day (early-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 4.49 mg/day (early-confidence extraction from PubMed abstracts).[1351,, etc.]
Clinical Depth
Humans: 194 • RCTs: 3 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 686 • Interactions: 812
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
451 total studies · 2 recent
Timeline
In vitro / tissue
2,077
Animal-only studies
1,812
Interaction signals
812
Safety adverse signals
686
Total indexed
451
Human studies
194
Weighted direction score: 21 (Positive Lean)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
In vitro / tissue
2,077
Animal-only studies
1,812
Interaction signals
812
Safety adverse signals
686
Total indexed
451
Human studies
194
Randomized trials
3
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 30041489 • 2018 Jul 23
Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies.
Nutrients
Open PubMedPMID 9459373 • 1998 Feb
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.
Am J Clin Nutr
Open PubMedPMID 19158208 • 2009 Mar
Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women.
Am J Clin Nutr
Benefit reports: 5
Adverse reports: 2
No-effect reports: 0
Mixed reports: 3
Unclear reports: 0
Signal confidence: 0.50
Benefits
Adverse
No Effect
Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 7 mentions (confidence 0.50) across Biohackers, sleep, longevity, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
post • r/Biohackers • mixed
Glycine, inositol & apigenin for insomnia - do I need to cycle these for them to be effective Recently started taking Glycine, inositol & apigenin for insomnia - do I need to cycle these for them to be effective?? Or can I take them consis…
Open mentionpost • r/sleep • mixed
Spent 2 Years Fixing My Insomnia. Here Is My Honest Tier List of Supplements. I’ve had "wake up at 3 AM and stare at the wall" insomnia for years. I got sick of reading articles written by bots, so I spent way too much money testing this s…
Open mentionpost • r/longevity • unclear
Apigenin May Reduce Senescence and Cancer | Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular feat…
amazon
Amazon search for Apigenin
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 194, RCTs 3, meta-analyses 1.[1351,1895,3062, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30041489 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,, etc.]
PMID 10615220 • 1999 Jun
Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects.
Br J Nutr
Open PubMedPMID 30875872 • 2019 Mar 15
The Therapeutic Potential of Apigenin.
Int J Mol Sci
Open PubMedPMID 37707699 • 2024 Sep
Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions.
Mol Cell Biochem
Open PubMedPMID 40178511 • 2025 Apr 15
Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis.
ACS Nano
Open PubMedPMID 32418173 • 2020 Sep
Soy Isoflavones and Gastrointestinal Health.
Curr Nutr Rep
Open PubMedPMID 34749613 • 2022
Effects of Flavonoids in Experimental Models of Arterial Hypertension.
Curr Top Med Chem
Open PubMedPMID 35998830 • 2022 Nov
Apigenin and its dermatological applications: A comprehensive review.
Phytochemistry
Open PubMedPerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 4.49 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Legacy community note: Surging popularity after Huberman Lab promotion. Users report notably better sleep quality when taken with magnesium and L-theanine. The "Huberman sleep stack" (apigenin + magnesium + theanine) is widely adopted.
post • r/Biohackers • mixed
Desperate: Terrible sleep, despite good sleep hygiene and no sleep apnea - I'll e-send $100 to any helpful intervention. I saw someone post similar so I thought I would give my specifics to the community in hopes that the brilliant minds h…
Open mentionpost • r/Supplements • benefit
I Tried 15+ Supplements for Better Sleep & Recovery - Here's What Actually Moved the Needle Hey r/supplements, wanted to share my experience after spending way too much money experimenting with sleep and recovery supplements over the past …
Open mentionpost • r/HubermanLab • benefit
My Breakdown of Andrew Huberman's Complete Longevity Protocol I've read so many garbage AI writeups on Huberman's routine in this sub that just regurgitate the same surface-level stuff, so I decided to actually dig into all his podcast epi…
Open mentionpost • r/Biohackers • benefit
Recovering from years of alcoholism: all the data after 1,500 days of rebuilding **Disclaimer: This is an N=1, just my personal experience anecdotally. Nothing more, nothing less.** I don't post often, but this milestone felt worth sharing…
Open mentionpost • r/Supplements • benefit
Increase in Testosterone regiment that worked for me Hi, I've seen a lot of posts here asking how to increase yout tes levels, see below my regiment that worked for me, bear in mind that everyone is different (I am 35M who used to do a lot…
Open mentioncomment • r/Biohackers • unclear
Glycine is structural and doesn’t need to be cycled. Inositol & Apigenin should be cycled, to prevent desensitisation. Inositol: 5 days on/ 2 off Apigenin: 3 weeks on/ 1 off
Open mentionCommunity Sources
PUBMED • 1998 • Human evidence curation set
PMID 9459373 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19158208 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 1999 • Human evidence curation set
PMID 10615220 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30875872 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37707699 from Mol Cell Biochem.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40178511 from ACS Nano.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32418173 from Curr Nutr Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34749613 from Curr Top Med Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35998830 from Phytochemistry.
Outcome: See linked PubMed abstract for methods and outcomes.[1351,1895,3062, etc.]
Open source