Session check

Supplement

Berberine

Activates AMPK-linked pathways and supports glycemic control.[1836,2625,3691, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Metabolic HealthBody CompositionLongevity

Composite Rating

3.8/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Moderate

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 15 • mentions 16 • links 26

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Metabolic Health, Body Composition, Longevity.[67,335,361, etc.]

Dose guide: Human-study daily dose: 500 mg-1500 mg/day (moderate-confidence extraction from PubMed abstracts)..[67,335,361, etc.]

Category: botanical.[67,335,361, etc.]

At-A-Glance Evidence Architecture[1836,2625,3691, etc.]

Clinical Depth

Humans: 287 • RCTs: 41 • Meta: 15

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 887 • Interactions: 1,133

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

552 total studies · 4 recent

Timeline

20082025

Top Signal Metrics[1836,2625,3691, etc.]

Animal-only studies

3,020

In vitro / tissue

2,127

Interaction signals

1,133

Safety adverse signals

887

Total indexed

552

Human studies

287

Community Direction Mix[67,335,361, etc.]

Weighted direction score: 1 (Mixed / Neutral)

Benefit

Evidence Quality Summary[1836,2625,3691, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Animal-only studies

3,020

In vitro / tissue

2,127

Interaction signals

1,133

Safety adverse signals

887

Total indexed

552

Human studies

287

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a15

Randomized TrialsLevel 1b41

Human Studies (other)Level 3-4231

All IndexedAll levels552

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1836,2625,3691, etc.]

PMID 32690176 • 2020 Aug

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.

Clin Nutr ESPEN

Open PubMed

PMID 35988871 • 2022 Sep

A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.

Pharmacol Res

Open PubMed

PMID 37675930 • 2023 Dec

Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials.

Community Report Frequency[67,335,361, etc.]

Benefit reports: 7

Adverse reports: 6

No-effect reports: 0

Mixed reports: 3

Unclear reports: 0

Signal confidence: 0.52

Top Reported Effects[67,335,361, etc.]

Benefits

weight loss: 4
effective: 2
better: 2
improved: 1
worked: 1
helped: 1
reduced: 1
energy: 1

Adverse

anxiety: 2
bloating: 2
side effects: 2
diarrhea: 2
constipation: 1
insomnia: 1
nausea: 1
cramps: 1

No Effect

hard to tell: 1

High empirical usage in glucose-management stacks. | Step2: Insufficient empirical signal for a directional adjustment.

Reddit evidence: 13 mentions (confidence 0.52) across Biohackers, Supplements.

Community Evidence Examples[67,335,361, etc.]

post • r/Biohackers • mixed

Berberine and obesity legit potential or just another supplement hype? I came across this new research paper on arXiv that reviews berberine, a plant compound you see in a lot of herbal supplements, as a possible treatment for obesity. Wha…

Open mention

post • r/Supplements • benefit

How effective is berberine from slow Hey peeps! So I’m badly wanting to reduce my weight and tummy..but somehow I end up eating more as Im a foodie! Does this berberine really would help me cutting my appetite?

Open mention

post • r/Supplements • mixed

Can i take berberine with other supplements? I am 26 F, I have pcos and have also been managing pvcs naturally. I used to take berberine and it worked really well to help me lower my A1C. I stopped taking it after my levels were better. I …

Retail Signal Examples

amazon

Amazon search for Berberine

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1836,2625,3691, etc.]

1. Berberine and glycemic markers

META_ANALYSIS • 2023 • Adults

Type 2 diabetes and metabolic syndrome cohorts.

Outcome: Reduces fasting glucose and HbA1c in many trials.[1836,2625,3691, etc.]

2. PubMed evidence summary: Berberine

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 287, RCTs 41, meta-analyses 15.[1836,2625,3691, etc.]

Open source

Implementation Blueprint

At-A-Glance Evidence Architecture[1836,2625,3691, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1836,2625,3691, etc.]

Community Direction Mix[67,335,361, etc.]

Evidence Quality Summary[1836,2625,3691, etc.]

Study Type Breakdown

Top Human Studies[1836,2625,3691, etc.]

Community Report Frequency[67,335,361, etc.]

Top Reported Effects[67,335,361, etc.]

Community Evidence Examples[67,335,361, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1836,2625,3691, etc.]

Safety and Pitfalls