Supplement
Supports digestive or fibrinolytic enzymatic pathways.[2662,3003,3337, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
94/100
High depth from human/RCT/meta counts
Community Direction
-20
Caution Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 3 • links 22
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Gut Health, Recovery, Metabolic Health, Longevity.[472,632,817, etc.]
Dose guide: Human-study daily dose: 50 mg-350 mg/day (higher-confidence extraction from PubMed abstracts)..[472,632,817, etc.]
Category
Enzyme
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 50 mg-350 mg/day (higher-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 50 mg-350 mg/day (higher-confidence extraction from PubMed abstracts).[,, etc.]
Clinical Depth
Humans: 65 • RCTs: 18 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 124 • Interactions: 164
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
148 total studies · 4 recent
Timeline
Animal-only studies
553
In vitro / tissue
355
Interaction signals
164
Total indexed
148
Safety adverse signals
124
Human studies
65
Weighted direction score: -20 (Caution Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
553
In vitro / tissue
355
Interaction signals
164
Total indexed
148
Safety adverse signals
124
Human studies
65
Randomized trials
18
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 38542694 • 2024 Mar 9
An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study.
Nutrients
Open PubMedPMID 39929877 • 2025 Feb 10
Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery.
Sci Rep
Open PubMedPMID 27412590 • 2016 Oct
Bromelain and cardiovascular risk factors in diabetes: An exploratory randomized, placebo controlled, double blind clinical trial.
Benefit reports: 1
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
aggregate • unclear
Aggregate community signal: 3 directional mentions (benefit 1, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Bromelain
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 65, RCTs 18, meta-analyses 0.[2662,3003,3337, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38542694 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
Chin J Integr Med
PMID 32660675 • 2021 Jan 28
Combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status in adults: a double-blind placebo-controlled randomised crossover clinical trial.
Br J Nutr
Open PubMedPMID 39977849 • 2025 Jun 1
COMBINED INTRAVITREAL AFLIBERCEPT AND ANTI-INFLAMMATORY ORAL SUPPLEMENTATION IN THE TREATMENT OF DIABETIC MACULAR EDEMA: Two-Year Randomized Controlled Trial Results.
Retina
Open PubMedPMID 41315628 • 2025 Nov 28
Effects of bromelain supplementation on disease activity and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled study.
Sci Rep
Open PubMedPMID 37146985 • 2023 Jul 1
Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review.
J Sport Rehabil
Open PubMedPMID 37650738 • 2023 Sep 19
Bromelain: a review of its mechanisms, pharmacological effects and potential applications.
Food Funct
Open PubMedPMID 31233691 • 2019
[Pineapple juice nutritional profile].
Vopr Pitan
Open PubMedPMID 37202035 • 2023 Jun
Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.
Clin Nutr ESPEN
Open PubMedPMID 29726290 • 2018 Sep
Alpha lipoic acid in obstetrics and gynecology.
Gynecol Endocrinol
Open PubMedPerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22bromelain%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22bromelain%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=bromelain
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 50 mg-350 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 1 PubMed studies (mg/day).
AnalyzeAndOptimize Instagram mentions: 1.
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$12.00.
Community Sources
PUBMED • 2025 • Human evidence curation set
PMID 39929877 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27412590 from Chin J Integr Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32660675 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39977849 from Retina.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41315628 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37146985 from J Sport Rehabil.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37650738 from Food Funct.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31233691 from Vopr Pitan.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37202035 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29726290 from Gynecol Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[2662,3003,3337, etc.]
Open source