Session check

Supplement

Calcium Citrate

Supports electrolyte balance, enzymatic activity, and metabolic signaling.[1328,1420,1439, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Metabolic HealthEnergyHeart HealthLongevity

Composite Rating

4.0/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Positive Lean • confidence Moderate

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 15 • mentions 9 • links 26

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[58,227,355, etc.]

Dose guide: Human-study daily dose: 555 mg-1100 mg/day (higher-confidence extraction from PubMed abstracts)..[58,227,355, etc.]

Category: mineral.[58,227,355, etc.]

At-A-Glance Evidence Architecture[1328,1420,1439, etc.]

Clinical Depth

Humans: 205 • RCTs: 75 • Meta: 2

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 40 • Interactions: 27

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

255 total studies · 2 recent

Timeline

19992024

Top Signal Metrics[1328,1420,1439, etc.]

Total indexed

255

Human studies

205

Randomized trials

Animal-only studies

In vitro / tissue

Safety adverse signals

Community Direction Mix[58,227,355, etc.]

Weighted direction score: 63 (Positive Lean)

Benefit7 (78%)

Evidence Quality Summary[1328,1420,1439, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Total indexed

255

Human studies

205

Randomized trials

Animal-only studies

In vitro / tissue

Safety adverse signals

Interaction signals

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a2

Randomized TrialsLevel 1b75

Human Studies (other)Level 3-4128

All IndexedAll levels255

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1328,1420,1439, etc.]

PMID 33872340 • 2021

Effect of dietary treatment and fluid intake on the prevention of recurrent calcium stones and changes in urine composition: A meta-analysis and systematic review.

PLoS One

Open PubMed

PMID 11329115 • 1999 Nov

Meta-analysis of calcium bioavailability: a comparison of calcium citrate with calcium carbonate.

Am J Ther

Open PubMed

PMID 35623880 • 2022 Jun

Urate-lowering effect of calcium supplementation: Analyses of a randomized controlled trial.

Clin Nutr ESPEN

Community Report Frequency[58,227,355, etc.]

Benefit reports: 7

Adverse reports: 1

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.44

Top Reported Effects[58,227,355, etc.]

Benefits

better: 7
energy: 1
sleep: 1
reduced: 1
helpful: 1

Adverse

insomnia: 1

No Effect

insufficient no-effect reports captured: 0

Strong positive empirical sentiment with adequate confidence; boost recommendation priority.

Reddit evidence: 8 mentions (confidence 0.44) across Supplements, Biohackers.

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [ERROR].

terminated

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Community Evidence Examples[58,227,355, etc.]

post • r/Supplements • unclear

Kidney pain from calcium citrate supplements? Adding it to my water and it causes intermittent stinging pain 48h after. I had the same thing with eggshells powder or bone powder. Anyone experienced this? Thanks

Open mention

post • r/Supplements • unclear

Best calcium supplement for absorption other than calcium citrate? I have issues with slow mao-a activity and calcium supplements help me. I'm trying to figure out which calcium supplement is the best absorption with all these new products…

Open mention

post • r/Biohackers • unclear

Is pure calcium citrate powder a good form of supplementation? I probably have a calcium defiency and I was browsing around products, but I've mostly found supplements with calcium carbonate (which has supposedly a low absorption rate) or …

Retail Signal Examples

amazon

Amazon search for Calcium Citrate

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1328,1420,1439, etc.]

1. PubMed evidence summary: Calcium Citrate

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 205, RCTs 75, meta-analyses 2.[1328,1420,1439, etc.]

Open source

2. Effect of dietary treatment and fluid intake on the prevention of recurrent calcium stones and changes in urine composition: A meta-analysis and systematic review.

PUBMED • 2021 • Human evidence curation set

PMID 33872340 from PLoS One.

Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[1328,1420,1439, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1328,1420,1439, etc.]

Community Direction Mix[58,227,355, etc.]

Evidence Quality Summary[1328,1420,1439, etc.]

Study Type Breakdown

Top Human Studies[1328,1420,1439, etc.]

Community Report Frequency[58,227,355, etc.]

Top Reported Effects[58,227,355, etc.]

Community Evidence Examples[58,227,355, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1328,1420,1439, etc.]

Safety and Pitfalls