Supplement
Supports broad cellular function with category-specific mechanisms.[1745,1763,2015, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
53
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 7 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[9,100,318, etc.]
Dose guide: Human-study daily dose: 5100 mg/day (moderate-confidence extraction from PubMed abstracts)..[9,100,318, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 5100 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 5100 mg/day (moderate-confidence extraction from PubMed abstracts).[1745,, etc.]
Clinical Depth
Humans: 197 • RCTs: 15 • Meta: 7
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 159 • Interactions: 217
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
338 total studies · 2 recent
Timeline
Total indexed
338
Animal-only studies
299
In vitro / tissue
239
Interaction signals
217
Human studies
197
Safety adverse signals
159
Weighted direction score: 53 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
338
Animal-only studies
299
In vitro / tissue
239
Interaction signals
217
Human studies
197
Safety adverse signals
159
Randomized trials
15
Meta-analyses
7
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 38999738 • 2024 Jun 22
Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis.
Nutrients
Open PubMedPMID 17597571 • 2007 Jul
Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.
Lancet Infect Dis
Open PubMedPMID 40311928 • 2025 Jun
Efficacy and safety of Echinacea purpurea in treating upper respiratory infections and complications of otitis media in children: Systematic review and meta-analysis.
Clin Nutr ESPEN
Benefit reports: 5
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.36
Benefits
Adverse
No Effect
Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 4 mentions (confidence 0.36) across Biohackers, Supplements, HubermanLab, sleep.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Biohackers • mixed
The Effects of Echinacea on Anxiety **Background/Objectives**: *Echinacea* extracts with unique alkamide profiles (EP107™) have been shown to affect upper respiratory tract infections and reduce anxiety in both animals and humans. However,…
Open mentionpost • r/Biohackers • unclear
Echinacea root Anyone have experience taking this supplement on a daily basis. Using it to boost immune system thru flu season.
Open mentionpost • r/Supplements • unclear
Echinacea root
Open mentionamazon
Amazon search for Echinacea
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 197, RCTs 15, meta-analyses 7.[1745,1763,2015, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38999738 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,, etc.]
PMID 33809656 • 2021 Mar 16
Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 30465062 • 2019 Mar
Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children.
Eur J Clin Pharmacol
Open PubMedPMID 24456264 • 2013 Dec
Immunopharmacology of the main herbal supplements: a review.
Endocr Metab Immune Disord Drug Targets
Open PubMedPMID 35630063 • 2022 May 9
Echinacea angustifolia and Echinacea purpurea Supplementation Combined with Vaginal Hyaluronic Acid to Boost the Remission of Cervical Low-Grade Squamous Intraepithelial Lesions (L-SILs): A Randomized Controlled Trial.
Medicina (Kaunas)
Open PubMedPMID 17436202 • 2007 Sep
Echinacea purpurea and mucosal immunity.
Int J Sports Med
Open PubMedPMID 21173411 • 2010 Dec 21
Echinacea for treating the common cold: a randomized trial.
Ann Intern Med
Open PubMedPMID 26317662 • 2016
Echinacea-Based Dietary Supplement Does Not Increase Maximal Aerobic Capacity in Endurance-Trained Men and Women.
J Diet Suppl
Open PubMedPMID 21747102 • 2011 Jul-Aug
Placebo effects and the common cold: a randomized controlled trial.
Ann Fam Med
Open PubMedPMID 31111049 • 2019
Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study.
Biomed Res Int
Open PubMedPMID 28762712 • 2017 Jul 15
Common Herbal Dietary Supplement-Drug Interactions.
Am Fam Physician
Open PubMedPMID 36364865 • 2022 Nov 1
Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.
Nutrients
Open PubMedPMID 27055821 • 2017 Jan
Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies.
J Evid Based Complementary Altern Med
Open PubMedHuman-study daily dose signal: 5100 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$12.00.
Legacy community note: Extremely popular in longevity, biohacking, and mental health communities. "GlyNAC" (NAC + glycine) gaining massive traction after aging reversal study. Users report clearer thinking, better breathing, improved liver markers, and reduced compulsive behaviors.
post • r/Biohackers • unclear
Trying to avoid catching coughs may be a good idea, as these can be viruses that lead to long-term health problems. Colds on the other hand pose no danger There is [increasing research](https://me-pedia.org/wiki/List_of_chronic_diseases_li…
Open mentionpost • r/HubermanLab • benefit
Natural Immune Health Flu season got me early this year! I was listening to the Huberman episode on immune health. I only supplement where I can't solve the problem with my nutrition first, so I created a list of ingredients that actually …
Open mentionpost • r/Supplements • unclear
Why zinc has a bad effect on me ? Why do I feel sad every time I take zinc? Even if I take it in the morning, I have sad dreams at night. I don't know how to properly expalin this.. It almost makes me feel depressed. I read that it's suppo…
Open mentionpost • r/Supplements • benefit
Retired Olly Elderberry vs. new Active Immunity The differences seem to be: • Almost double the Vit C • Eliminated the Vit D • Added selenium • Added echinacea • Significantly reduced elderberry • Only 15 servings per bottle now (vs. 30 be…
Open mentionpost • r/sleep • benefit
What in this is helping me sleep? Hi, so I've struggled with sleep for like 1.5 years now. Usually I can get to sleep fine but It feels like I struggle to enter a deep sleep or REM and I wake up constantly through the night. I wake up tire…
Open mentionCommunity Sources
PUBMED • 2007 • Human evidence curation set
PMID 17597571 from Lancet Infect Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40311928 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33809656 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30465062 from Eur J Clin Pharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 24456264 from Endocr Metab Immune Disord Drug Targets.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35630063 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17436202 from Int J Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 21173411 from Ann Intern Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26317662 from J Diet Suppl.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21747102 from Ann Fam Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31111049 from Biomed Res Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28762712 from Am Fam Physician.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36364865 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27055821 from J Evid Based Complementary Altern Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1745,1763,2015, etc.]
Open source