Session check

Supplement

Fisetin

Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2969,3374,3863, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Stress ResilienceMoodImmune SupportLongevity

Composite Rating

3.3/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

77/100

High depth from human/RCT/meta counts

Community Direction

Positive Lean • confidence Minimal

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 11 • mentions 3 • links 21

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[499,647,870, etc.]

Dose guide: Human-study daily dose: 100 mg-200 mg/day (higher-confidence extraction from PubMed abstracts)..[499,647,870, etc.]

Category: botanical.[499,647,870, etc.]

At-A-Glance Evidence Architecture[2969,3374,3863, etc.]

Clinical Depth

Humans: 61 • RCTs: 5 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 157 • Interactions: 214

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

125 total studies · 5 recent

Timeline

20182026

Top Signal Metrics[2969,3374,3863, etc.]

In vitro / tissue

435

Animal-only studies

414

Interaction signals

214

Safety adverse signals

157

Total indexed

125

Human studies

Community Direction Mix[499,647,870, etc.]

Weighted direction score: 33 (Positive Lean)

Benefit

Evidence Quality Summary[2969,3374,3863, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

In vitro / tissue

435

Animal-only studies

414

Interaction signals

214

Safety adverse signals

157

Total indexed

125

Human studies

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b5

Human Studies (other)Level 3-456

All IndexedAll levels125

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[2969,3374,3863, etc.]

PMID 29541713 • 2018 Apr 25

Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.

Food Funct

Open PubMed

PMID 31434498 • 2019 Jan-Dec

Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.

Clin Appl Thromb Hemost

Open PubMed

PMID 34809689 • 2021 Nov 22

Effect of fermented Rhus verniciflua stokes extract on liver function parameters in healthy Korean adults: a double-blind randomized controlled trial.

Community Report Frequency[499,647,870, etc.]

Benefit reports: 2

Adverse reports: 1

No-effect reports: 0

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[499,647,870, etc.]

Benefits

Senolytic cell clearance (anti-aging): 1
Anti-inflammatory: 1
Neuroprotective: 1
May extend healthspan: 1
Antioxidant protection: 1
May support cognitive function: 1

Adverse

Pregnancy: 1
Children: 1
Those wanting to wait for more human data: 1

No Effect

insufficient no-effect reports captured: 0

Insufficient empirical signal for a directional adjustment.

Reddit evidence: 0 mentions (confidence 0.00).

Amazon signal: 0 products scanned (confidence 0.00).

Community Evidence Examples[499,647,870, etc.]

aggregate • benefit

Aggregate community signal: 3 directional mentions (benefit 2, adverse 1, no-effect 0, mixed 0).

Open mention

Retail Signal Examples

amazon

Amazon search for Fisetin

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[2969,3374,3863, etc.]

1. PubMed evidence summary: Fisetin

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 61, RCTs 5, meta-analyses 0.[2969,3374,3863, etc.]

Open source

2. Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.

PUBMED • 2018 • Human evidence curation set

PMID 29541713 from Food Funct.

Outcome: See linked PubMed abstract for methods and outcomes.[2969,, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[2969,3374,3863, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[2969,3374,3863, etc.]

Community Direction Mix[499,647,870, etc.]

Evidence Quality Summary[2969,3374,3863, etc.]

Study Type Breakdown

Top Human Studies[2969,3374,3863, etc.]

Community Report Frequency[499,647,870, etc.]

Top Reported Effects[499,647,870, etc.]

Community Evidence Examples[499,647,870, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[2969,3374,3863, etc.]

Safety and Pitfalls