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Supplement

Glucosamine + Chondroitin

Structural building blocks for cartilage proteoglycans; may slow cartilage degradation and modulate inflammation.[1342,1359,1360, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence
Joint HealthRecoveryalias: glucosaminealias: chondroitinalias: glucosamine sulfate

Composite Rating

3.9/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

37

Positive Lean • confidence Low

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 11 • links 341

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Joint Health, Recovery.[50,232,324, etc.]

Dose guide: Glucosamine sulfate 1500 mg + Chondroitin sulfate 1200 mg /day.[50,232,324, etc.]

Category: other.[50,232,324, etc.]

Category

Other

Evidence Tier

ROBUST

Daily Guide

Glucosamine sulfate 1500 mg + Chondroitin sulfate 1200 mg /day

Dosing Guide

Glucosamine sulfate 1500 mg + Chondroitin sulfate 1200 mg /day[1342,1359,, etc.]

At-A-Glance Evidence Architecture[1342,1359,1360, etc.]

Clinical Depth

Humans: 444 • RCTs: 47 • Meta: 16

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 581 • Interactions: 2,780

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

801 total studies · 44 recent

Timeline

19892026

Top Signal Metrics[1342,1359,1360, etc.]

Animal-only studies

9,526

In vitro / tissue

3,929

Interaction signals

2,780

Total indexed

801

Safety adverse signals

581

Human studies

444

Community Direction Mix[50,232,324, etc.]

Weighted direction score: 37 (Positive Lean)

Benefit

Evidence Quality Summary[1342,1359,1360, etc.]

≥2 meta-analyses OR (≥5 RCTs AND ≥25 human studies).

Animal-only studies

9,526

In vitro / tissue

3,929

Interaction signals

2,780

Total indexed

801

Safety adverse signals

581

Human studies

444

Randomized trials

47

Meta-analyses

16

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a16
Randomized TrialsLevel 1b47
Human Studies (other)Level 3-4381
All IndexedAll levels801
100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1342,1359,1360, etc.]

PMID 25629804 • 2015 Jan 28

Chondroitin for osteoarthritis.

The Cochrane database of systematic reviews

Open PubMed

PMID 10732937 • 2000 Mar 15

Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

JAMA

Open PubMed

PMID 30879253 • 2019 May

Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.

Advances in therapy

Open PubMed

Community Report Frequency[50,232,324, etc.]

Benefit reports: 7

Adverse reports: 2

No-effect reports: 1

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.28

Top Reported Effects[50,232,324, etc.]

Benefits

  • sleep: 1
  • recovery: 1
  • weight loss: 1
  • better: 1
  • works: 1

Adverse

  • Shellfish allergy (use vegan source): 1
  • May affect blood sugar in diabetics: 1

No Effect

  • no noticeable effect: 1

Sulfate form specifically is the evidence-backed version. Response is individual. | Step2: Aggregated empirical signal from 2 mapped records.

Reddit evidence: 3 mentions (confidence 0.28) across Biohackers, Supplements.

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

Community Evidence Examples[50,232,324, etc.]

post • r/Biohackers • benefit

My biohacking journey as a middle aged overweight guy 12 months ago I was very unhealthy - 123kg (271lb), cholesterol >8, elevated liver enzymes, hypertension. The typical lazy 40 year old white collar male. Desk job, no exercise, high str…

Open mention

post • r/Supplements • unclear

I feel like it's excessive, what could I cut out? B12 - getting mouth ulcers (aphthas) without it Magnesium - eyelids are twitching without it Glucosamine Chondroitin MSM and collagen - my joints are loud as heck (doc said it's nothing to …

Open mention

post • r/Supplements • benefit

Any recommendations on joint supplements??? Good grief there’s a dang sub for *everything* it seems & took me posting & getting removed a couple times before I was pointed here. *ANYWAY…* I am an almost-43 y/o female cashier that has to be…

Retail Signal Examples

amazon

Amazon search for Glucosamine + Chondroitin

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22chondroitin%22)%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22chondroitin%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22chondroitin%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D

Scientific Evidence Notes[1342,1359,1360, etc.]

1. Glucosamine for knee osteoarthritis: Cochrane review of 43 RCTs

META_ANALYSIS • 2015 • Adults

43 RCTs with 9110 knee OA patients.

Outcome: Glucosamine sulfate (crystalline) reduced pain (SMD −0.47) and improved WOMAC function; non-crystalline and HCl forms showed less consistent benefit.[1342,1359,1360, etc.]

Open source
2. GAIT trial: glucosamine, chondroitin for knee OA pain

RCT • 2006 • Adults

1583 patients in NIH-funded factorial RCT.

Outcome: Combination glucosamine+chondroitin provided significant pain relief in moderate-to-severe OA subgroup (79.2% vs 54.3% placebo) but not overall population.[1342,1359,, etc.]

1360

Safety and Pitfalls

  • 6-8 weeks needed for benefit onset. Vegetarian glucosamine available.[50,232,324, etc.]
  • Potential side effect: GI upset[50,232,324, etc.]
  • Potential side effect: headache[50,232,324, etc.]
  • Use caution with condition: shellfish allergy (glucosamine from shellfish)[50,232,324, etc.]
  • Interaction check: warfarin (may enhance anticoagulation)[50,232,324, etc.]
  • Legacy caution group: Shellfish allergy (use vegan source)[50,232,324, etc.]
  • Legacy caution group: May affect blood sugar in diabetics[50,232,324, etc.]
7 (64%)
Adverse2 (18%)
No Effect1 (9%)
Mixed1 (9%)

PMID 26592799 • 2016 Jan

Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies.

Neuroscience and biobehavioral reviews

Open PubMed

PMID 40664872 • 2025 Jul 15

Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

Scientific reports

Open PubMed

PMID 21969261 • 2012 Mar 15

Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.

Journal of the science of food and agriculture

Open PubMed

PMID 29947998 • 2018 Aug

Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.

Rheumatology international

Open PubMed

PMID 31470599 • 2019 Aug 29

Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Nutrients

Open PubMed

PMID 29018060 • 2018 Feb

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

British journal of sports medicine

Open PubMed

PMID 26822714 • 2016 Jan 29

Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.

Nutrition journal

Open PubMed

PMID 39982001 • 2025 Feb 2

Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial.

Age and ageing

Open PubMed

PMID 35458170 • 2022 Apr 12

A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.

Nutrients

Open PubMed

PMID 31381494 • 2019 Sep

A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis.

Journal of medicinal food

Open PubMed

PMID 33592868 • 2021 Feb 5

The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.

Medicine

Open PubMed

PMID 31221944 • 2019 Sep

Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.

Alternative therapies in health and medicine

Open PubMed

PMID 24395557 • 2015 May

Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens.

Annals of the rheumatic diseases

Open PubMed

PMID 26604721 • 2015

Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.

Clinical interventions in aging

Open PubMed

PMID 26178634 • 2016 Apr

Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial.

Aging clinical and experimental research

Open PubMed

PMID 26937646 • 2016 Jun

The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study.

European journal of physical and rehabilitation medicine

Open PubMed

PMID 36715012 • 2023

Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.

Nutrition and cancer

Open PubMed

PMID 12860582 • 2003 Jul 14

The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.

Archives of internal medicine

Open PubMed

PMID 30859538 • 2019 Spring

Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals

Open PubMed

PMID 24866892 • 2015 Mar

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

The American journal of sports medicine

Open PubMed

PMID 29713967 • 2018 Sep

Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.

Clinical rheumatology

Open PubMed

PerimeterX / captcha block encountered.

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Human-study daily dose signal: 1200 mg/day (confidence MEDIUM).

Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).

AnalyzeAndOptimize Instagram mentions: 1.

Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).

Legacy community note: Very widely used with mixed experiences. Many elderly users report meaningful joint pain relief. Some studies are less impressive. Glucosamine SULFATE form is strongly preferred. Best results over longer periods (8+ weeks).

Open mention

post • r/Supplements • unclear

Almost 32 year old looking for long term health I am mostly concerned with long term joint pain and gut health, along with boosting my immune system because I have a 2yo in daycare and a 5 month old baby. I want to live long and feel good …

Open mention

comment • r/Supplements • unclear

Glucosamine sulfate is a must try with or with out chondroitin sulfate. Some people do okay on the less expensive glucosamine HCl. You might get a CRP blood test looking for high inflammation and vitamin D test. my mother's high CRP came d…

Open mention

comment • r/Supplements • benefit

I found a lot more success personally in decreasing inflammatory foods I eat like refined sugars and seed oils compared to supplementing my way out of the problem. Many are expensive like MSM and glucosamine or chondroitin. Only supplement…

Open mention
https://pubmed.ncbi.nlm.nih.gov/?term=(%22chondroitin%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22chondroitin%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%202018%3A3000%5Bpdat%5D
  • https://pubmed.ncbi.nlm.nih.gov/25629804/
  • https://pubmed.ncbi.nlm.nih.gov/10732937/
  • https://pubmed.ncbi.nlm.nih.gov/30879253/
  • https://pubmed.ncbi.nlm.nih.gov/26592799/
  • https://pubmed.ncbi.nlm.nih.gov/40664872/
  • https://pubmed.ncbi.nlm.nih.gov/21969261/
  • https://pubmed.ncbi.nlm.nih.gov/29947998/
  • https://pubmed.ncbi.nlm.nih.gov/31470599/
  • https://pubmed.ncbi.nlm.nih.gov/29018060/
  • https://pubmed.ncbi.nlm.nih.gov/26822714/
  • https://pubmed.ncbi.nlm.nih.gov/39982001/
  • https://pubmed.ncbi.nlm.nih.gov/35458170/
  • https://pubmed.ncbi.nlm.nih.gov/31381494/
  • https://pubmed.ncbi.nlm.nih.gov/33592868/
  • https://pubmed.ncbi.nlm.nih.gov/31221944/
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22chondroitin%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
    • https://old.reddit.com/r/Biohackers/comments/1mrs342/my_biohacking_journey_as_a_middle_aged_overweight/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Supplements/comments/1mcg5fn/i_feel_like_its_excessive_what_could_i_cut_out/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Supplements/comments/1q4eilw/any_recommendations_on_joint_supplements/.json?raw_json=1&sort=top&limit=25
    • https://www.instagram.com/p/DVOm90-jhyT/
    • https://www.reddit.com/search/?q=Glucosamine%20%2B%20Chondroitin
    1360
    Open source
    3. Glucosamine use and mortality: UK Biobank analysis

    COHORT • 2020 • Adults

    495,077 adults followed over 8 years.

    Outcome: Regular glucosamine use associated with 15% lower all-cause mortality (HR 0.85), 18% lower CVD mortality, and reduced CRP levels.[1342,1359,1360, etc.]

    Open source
    4. PubMed evidence summary: Glucosamine + Chondroitin

    PUBMED • Humans + preclinical triage

    Counts aggregated from automated literature sweep and tiering rules.

    Outcome: Tier HIGH; humans 1051, RCTs 131, meta-analyses 32.[1342,1359,1360, etc.]

    Open source
    5. Chondroitin for osteoarthritis.

    PUBMED • 2015 • Human evidence curation set

    PMID 25629804 from The Cochrane database of systematic reviews.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    6. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.

    PUBMED • 2000 • Human evidence curation set

    PMID 10732937 from JAMA.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    7. Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.

    PUBMED • 2019 • Human evidence curation set

    PMID 30879253 from Advances in therapy.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    8. Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies.

    PUBMED • 2016 • Human evidence curation set

    PMID 26592799 from Neuroscience and biobehavioral reviews.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    9. Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

    PUBMED • 2025 • Human evidence curation set

    PMID 40664872 from Scientific reports.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    10. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.

    PUBMED • 2012 • Human evidence curation set

    PMID 21969261 from Journal of the science of food and agriculture.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    11. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.

    PUBMED • 2018 • Human evidence curation set

    PMID 29947998 from Rheumatology international.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    12. Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

    PUBMED • 2019 • Human evidence curation set

    PMID 31470599 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    13. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

    PUBMED • 2018 • Human evidence curation set

    PMID 29018060 from British journal of sports medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    14. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.

    PUBMED • 2016 • Human evidence curation set

    PMID 26822714 from Nutrition journal.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    15. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial.

    PUBMED • 2025 • Human evidence curation set

    PMID 39982001 from Age and ageing.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    16. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.

    PUBMED • 2022 • Human evidence curation set

    PMID 35458170 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    17. A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis.

    PUBMED • 2019 • Human evidence curation set

    PMID 31381494 from Journal of medicinal food.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    18. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.

    PUBMED • 2021 • Human evidence curation set

    PMID 33592868 from Medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    19. Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.

    PUBMED • 2019 • Human evidence curation set

    PMID 31221944 from Alternative therapies in health and medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    20. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens.

    PUBMED • 2015 • Human evidence curation set

    PMID 24395557 from Annals of the rheumatic diseases.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    21. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.

    PUBMED • 2015 • Human evidence curation set

    PMID 26604721 from Clinical interventions in aging.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    22. Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial.

    PUBMED • 2016 • Human evidence curation set

    PMID 26178634 from Aging clinical and experimental research.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    23. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study.

    PUBMED • 2016 • Human evidence curation set

    PMID 26937646 from European journal of physical and rehabilitation medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    24. Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.

    PUBMED • 2023 • Human evidence curation set

    PMID 36715012 from Nutrition and cancer.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    25. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.

    PUBMED • 2003 • Human evidence curation set

    PMID 12860582 from Archives of internal medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    26. Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis.

    PUBMED • 2019 • Human evidence curation set

    PMID 30859538 from Journal of special operations medicine : a peer reviewed journal for SOF medical professionals.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    27. Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

    PUBMED • 2015 • Human evidence curation set

    PMID 24866892 from The American journal of sports medicine.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    28. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.

    PUBMED • 2018 • Human evidence curation set

    PMID 29713967 from Clinical rheumatology.

    Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]

    Open source
    29. [NON-ARTHROPLASTY TREATMENT FOR KNEE OSTEOARTHRITIS].

    META_ANALYSIS • 2017 • PubMed indexed study

    PMID 28786278 from Harefuah.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.1/10.[1342,1359,1360, etc.]

    Open source
    30. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review.

    SYSTEMATIC_REVIEW • 2025 • PubMed indexed study

    PMID 40647198 from Nutrients.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1342,1359,1360, etc.]

    Open source
    31. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.

    SYSTEMATIC_REVIEW • 2009 • PubMed indexed study

    PMID 19903416 from Health technology assessment (Winchester, England).

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1342,1359,1360, etc.]

    Open source
    32. Glucosamine and chondroitin for osteoarthritis?

    META_ANALYSIS • 2001 • PubMed indexed study

    PMID 11530541 from Bulletin on the rheumatic diseases.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]

    Open source
    33. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

    META_ANALYSIS • 2003 • PubMed indexed study

    PMID 12860572 from Archives of internal medicine.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]

    Open source
    34. A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review.

    META_ANALYSIS • 2010 • PubMed indexed study

    PMID 20631466 from The Physician and sportsmedicine.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]

    Open source
    35. Nutraceuticals in the management of osteoarthritis : a critical review.

    META_ANALYSIS • 2012 • PubMed indexed study

    PMID 23018608 from Drugs & aging.

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    Open source
    36. The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition: A Systematic Review of Evidence from Animal and Human Studies.

    SYSTEMATIC_REVIEW • 2019 • PubMed indexed study

    PMID 30704054 from Nutrients.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.0/10.[1342,1359,1360, etc.]

    Open source
    37. Randomised controlled trial: nutritional supplements to relieve irritable bowel syndrome symptoms by targeting the gut microbiota.

    RCT • 2025 • PubMed indexed study

    PMID 40692549 from Journal of nutritional science.

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    Open source
    38. Efficacy of Conservative Interventions for Musculoskeletal Conditions on Pain and Disability in Active Serving Military Personnel-A Systematic Review.

    SYSTEMATIC_REVIEW • 2024 • PubMed indexed study

    PMID 36722165 from Military medicine.

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    Open source
    39. The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis.

    SYSTEMATIC_REVIEW • 2019 • PubMed indexed study

    PMID 31376086 from Clinical rheumatology.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]

    Open source
    40. Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study.

    RCT • 2020 • PubMed indexed study

    PMID 32678677 from Journal of alternative and complementary medicine (New York, N.Y.).

    Outcome: Study design: RCT. Quality score: 8.7/10.[1342,1359,1360, etc.]

    Open source
    41. Nutrition/Dietary Supplements and Chronic Pain in Patients with Cancer and Survivors of Cancer: A Systematic Review and Research Agenda.

    SYSTEMATIC_REVIEW • 2021 • PubMed indexed study

    PMID 34323435 from Pain physician.

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    Open source
    42. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.

    RCT • 2017 • PubMed indexed study

    PMID 28790224 from Acta medica Indonesiana.

    Outcome: Study design: RCT. Quality score: 8.6/10.[1342,1359,1360, etc.]

    Open source
    43. Supplementary methods in the nonsurgical treatment of osteoarthritis.

    SYSTEMATIC_REVIEW • 2015 • PubMed indexed study

    PMID 25633815 from Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1342,1359,1360, etc.]

    Open source
    44. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative.

    SYSTEMATIC_REVIEW • 2014 • PubMed indexed study

    PMID 24387819 from Seminars in arthritis and rheumatism.

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    Open source
    45. Effect of danaparoid sodium on hard exudates in diabetic retinopathy.

    RCT • 1997 • PubMed indexed study

    PMID 9413466 from Lancet (London, England).

    Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]

    Open source
    46. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence.

    SYSTEMATIC_REVIEW • 2006 • PubMed indexed study

    PMID 16859534 from Arthritis research & therapy.

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    Open source
    47. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.

    RCT • 2010 • PubMed indexed study

    PMID 20525840 from Annals of the rheumatic diseases.

    Outcome: Study design: RCT. Quality score: 8.3/10.[1342,1359,1360, etc.]

    Open source
    48. Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.

    RCT • 2015 • PubMed indexed study

    PMID 25719429 from PloS one.

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    Open source
    49. Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial.

    RCT • 2025 • PubMed indexed study

    PMID 40162673 from Expert review of anti-infective therapy.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    50. The effects of chondroitin sulfate supplementation on indices of muscle damage induced by eccentric arm exercise.

    RCT • 2005 • PubMed indexed study

    PMID 16446690 from The Journal of sports medicine and physical fitness.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    51. Effect of prior aspirin use on stroke severity in the trial of Org 10172 in acute stroke treatment (TOAST).

    RCT • 2001 • PubMed indexed study

    PMID 11739983 from Stroke.

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    Open source
    52. Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health.

    RCT • 2022 • PubMed indexed study

    PMID 35956389 from Nutrients.

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    Open source
    53. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing.

    RCT • 2018 • PubMed indexed study

    PMID 30122200 from Nutrition research (New York, N.Y.).

    Outcome: Study design: RCT. Quality score: 7.9/10.[1342,1359,1360, etc.]

    Open source
    54. [Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].

    RCT • 2025 • PubMed indexed study

    PMID 40561485 from Terapevticheskii arkhiv.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    55. Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation.

    RCT • 2023 • PubMed indexed study

    PMID 37735385 from BMC musculoskeletal disorders.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    56. Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis.

    RCT • 2025 • PubMed indexed study

    PMID 41313018 from mSystems.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    57. Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.

    RCT • 2021 • PubMed indexed study

    PMID 34622845 from Medicine.

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    Open source
    58. Effects of glucosamine and chondroitin sulfate supplementation in addition to resistance exercise training and manual therapy in patients with knee osteoarthritis: A randomized controlled trial.

    RCT • 2022 • PubMed indexed study

    PMID 36156542 from JPMA. The Journal of the Pakistan Medical Association.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    59. Oral Bioavailability and Pharmacokinetics of Nonanimal Chondroitin Sulfate and Its Constituents in Healthy Male Volunteers.

    RCT • 2019 • PubMed indexed study

    PMID 30040242 from Clinical pharmacology in drug development.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    60. Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial.

    RCT • 2021 • PubMed indexed study

    PMID 33210408 from Phytotherapy research : PTR.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    61. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study.

    RCT • 2020 • PubMed indexed study

    PMID 33213125 from Reumatismo.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    62. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.

    RCT • 2021 • PubMed indexed study

    PMID 33685850 from Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    63. The PLE(2)NO self-management and exercise program for knee osteoarthritis: Study Protocol for a Randomized Controlled Trial.

    RCT • 2016 • PubMed indexed study

    PMID 27267755 from BMC musculoskeletal disorders.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    64. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins.

    RCT • 2015 • PubMed indexed study

    PMID 25732262 from Journal of photochemistry and photobiology. B, Biology.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    65. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?

    RCT • 2006 • PubMed indexed study

    PMID 17083356 from Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    66. Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids.

    RCT • 2005 • PubMed indexed study

    PMID 16359410 from Tropical medicine & international health : TM & IH.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    67. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.

    RCT • 2008 • PubMed indexed study

    PMID 18821708 from Arthritis and rheumatism.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    68. Potential effects of chondroitin sulfate on joint swelling: a GAIT report.

    RCT • 2008 • PubMed indexed study

    PMID 18768335 from Osteoarthritis and cartilage.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    69. Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease.

    RCT • 2010 • PubMed indexed study

    PMID 20108108 from Clinical rheumatology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    70. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee.

    RCT • 2010 • PubMed indexed study

    PMID 20179981 from Clinical rheumatology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    71. Danaparoid sodium lowers proteinuria in diabetic nephropathy.

    RCT • 1997 • PubMed indexed study

    PMID 9071714 from Journal of the American Society of Nephrology : JASN.

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    Open source
    72. [Anti-arthrosis treatments: efficacy and tolerance of chondroitin sulfates (CS 4&6)].

    RCT • 1998 • PubMed indexed study

    PMID 9856136 from Presse medicale (Paris, France : 1983).

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    73. [Results of the multicenter clinical trial of structum preparation in Russia].

    RCT • 2001 • PubMed indexed study

    PMID 11806217 from Terapevticheskii arkhiv.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    74. Testing a novel bioactive marine nutraceutical on osteoarthritis patients.

    RCT • 2013 • PubMed indexed study

    PMID 24189760 from Acta bio-medica : Atenei Parmensis.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    75. Epidermal growth factor and insulin use in corneal preservation. Results of a multi-center trial. The Corneal Preservation Study Group.

    RCT • 1994 • PubMed indexed study

    PMID 8115156 from Ophthalmology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    76. [Combined medication ARTRA in the treatment of osteoarthrosis].

    RCT • 2005 • PubMed indexed study

    PMID 16404866 from Terapevticheskii arkhiv.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    77. Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients.

    RCT • 2019 • PubMed indexed study

    PMID 29701488 from Journal of dietary supplements.

    Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.0/10.[1342,1359,1360, etc.]

    Open source
    78. Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study.

    COHORT • 2023 • PubMed indexed study

    PMID 36978077 from BMC medicine.

    Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]

    Open source
    79. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction.

    COHORT • 2024 • PubMed indexed study

    PMID 38180010 from Journal of dietary supplements.

    Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]

    Open source
    80. Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation.

    PUBMED • 2025 • PubMed indexed study

    PMID 39438142 from Zeitschrift fur Naturforschung. C, Journal of biosciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1342,1359,1360, etc.]

    Open source
    81. Dynamic hydrazone crosslinked salecan/chondroitin sulfate hydrogel platform as a promising wound healing Strategy: A comparative study on antibiotic and probiotic delivery.

    COHORT • 2024 • PubMed indexed study

    PMID 39241931 from International journal of pharmaceutics.

    Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]

    Open source
    82. Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence.

    PUBMED • 2021 • PubMed indexed study

    PMID 34884724 from International journal of molecular sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    83. Glucosamine/Chondroitin and Mortality in a US NHANES Cohort.

    COHORT • 2020 • PubMed indexed study

    PMID 33219063 from Journal of the American Board of Family Medicine : JABFM.

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    Open source
    84. Biological mechanisms of glycan- and glycosaminoglycan-based nutraceuticals.

    PUBMED • 2019 • PubMed indexed study

    PMID 31030758 from Progress in molecular biology and translational science.

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    Open source
    85. Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?

    COHORT • 2019 • PubMed indexed study

    PMID 31494830 from Advances in therapy.

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    Open source
    86. Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.

    PUBMED • 2020 • PubMed indexed study

    PMID 31957773 from Biomaterials science.

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    Open source
    87. European chondroitin sulfate and glucosamine food supplements: A systematic quality and quantity assessment compared to pharmaceuticals.

    COHORT • 2019 • PubMed indexed study

    PMID 31320062 from Carbohydrate polymers.

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    Open source
    88. [The efficacy and safety of intra-articular application of a combination of sodium hyaluronate and chondroitin sulfate for osteoarthritis of the knee: a multicenter prospective study].

    COHORT • 2020 • PubMed indexed study

    PMID 32598775 from Terapevticheskii arkhiv.

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    Open source
    89. Medical devices that look like medicines: safety and regulatory concerns for children in Europe.

    COHORT • 2020 • PubMed indexed study

    PMID 31533915 from Archives of disease in childhood.

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    Open source
    90. Dietary supplements for football.

    PUBMED • 2006 • PubMed indexed study

    PMID 16766503 from Journal of sports sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1342,1359,1360, etc.]

    Open source
    91. Nutraceutical therapies for degenerative joint diseases: a critical review.

    PUBMED • 2005 • PubMed indexed study

    PMID 16048146 from Critical reviews in food science and nutrition.

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    Open source
    92. New methods to diagnose and treat cartilage degeneration.

    PUBMED • 2009 • PubMed indexed study

    PMID 19786989 from Nature reviews. Rheumatology.

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    Open source
    93. Analytical aspects of pharmaceutical grade chondroitin sulfates.

    PUBMED • 2007 • PubMed indexed study

    PMID 17630645 from Journal of pharmaceutical sciences.

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    Open source
    94. Joint remedies.

    COHORT • 2002 • PubMed indexed study

    PMID 11771558 from Consumer reports.

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    Open source
    95. Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort.

    COHORT • 2011 • PubMed indexed study

    PMID 21598177 from Nutrition and cancer.

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    Open source
    96. The NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT).

    COHORT • 2008 • PubMed indexed study

    PMID 19062354 from Journal of pain & palliative care pharmacotherapy.

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    Open source
    97. Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis.

    PUBMED • 2025 • PubMed indexed study

    PMID 40500442 from Nature.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    98. Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study.

    PUBMED • 2024 • PubMed indexed study

    PMID 37819571 from Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    99. Chondroitin Sulfate-Based Nanocapsules as Nanocarriers for Drugs and Nutraceutical Supplements.

    PUBMED • 2024 • PubMed indexed study

    PMID 38892083 from International journal of molecular sciences.

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    Open source
    100. Sugar as a therapeutic target for the cognitive restoration following traumatic brain injury.

    PUBMED • 2019 • PubMed indexed study

    PMID 31609736 from Current opinion in neurology.

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    Open source
    101. Hyaluronan and chondroitin sulfate in chicken-vegetable bone broth delay osteoporosis progression.

    PUBMED • 2024 • PubMed indexed study

    PMID 38317402 from Journal of food science.

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    Open source
    102. TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy.

    PUBMED • 2021 • PubMed indexed study

    PMID 34930890 from Cell death & disease.

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    Open source
    103. Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation.

    PUBMED • 2020 • PubMed indexed study

    PMID 32107152 from Journal of bioscience and bioengineering.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    104. A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency.

    PUBMED • 2022 • PubMed indexed study

    PMID 35435595 from Lasers in medical science.

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    105. Cost-Effectiveness Assessment of Different Glucosamines in Patients with Knee Osteoarthritis: A Simulation Model Adapted to Germany.

    PUBMED • 2021 • PubMed indexed study

    PMID 33858318 from Current aging science.

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    106. Development of collagen-poly(caprolactone)-based core-shell scaffolds supplemented with proteoglycans and glycosaminoglycans for ligament repair.

    PUBMED • 2021 • PubMed indexed study

    PMID 33545824 from Materials science & engineering. C, Materials for biological applications.

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    107. Diet in Knee Osteoarthritis-Myths and Facts.

    PUBMED • 2025 • PubMed indexed study

    PMID 40507141 from Nutrients.

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    108. Supplementing Cancer?

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    109. The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.

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    110. The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences.

    PUBMED • 2005 • PubMed indexed study

    PMID 15636778 from Clinics in sports medicine.

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    Open source
    111. When food becomes a drug: nonanabolic nutritional supplement use in athletes.

    PUBMED • 2002 • PubMed indexed study

    PMID 12435662 from The American journal of sports medicine.

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    112. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 9.

    PUBMED • 2010 • PubMed indexed study

    PMID 20547670 from British journal of sports medicine.

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    113. Chondroitin Sulfate Safety and Quality.

    PUBMED • 2019 • PubMed indexed study

    PMID 31013685 from Molecules (Basel, Switzerland).

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    114. Galactosaminoglycans: Medical Applications and Drawbacks.

    PUBMED • 2019 • PubMed indexed study

    PMID 31374852 from Molecules (Basel, Switzerland).

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    Open source
    115. Thermal and storage stability of nutraceuticals in a milk beverage dietary supplement.

    PUBMED • 2007 • PubMed indexed study

    PMID 17995798 from Journal of food science.

    Outcome: Study design: OTHER. Quality score: 5.0/10.[1342,1359,1360, etc.]

    Open source
    116. Nutritional supplements for knee osteoarthritis--still no resolution.

    PUBMED • 2006 • PubMed indexed study

    PMID 16495399 from The New England journal of medicine.

    Outcome: Study design: OTHER. Quality score: 5.0/10.[1342,1359,1360, etc.]

    Open source
    117. Glucosamine and chondroitin for treating symptoms of osteoarthritis: evidence is widely touted but incomplete.

    PUBMED • 2000 • PubMed indexed study

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    118. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.

    PUBMED • 2016 • PubMed indexed study

    PMID 26728196 from Nutrition journal.

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    Open source
    119. Changes in Reported Dietary Supplement Use in Cognitively Normal National Alzheimer's Coordinating Center Participants Aged 55 and Older From 2015 to 2019.

    PUBMED • 2023 • PubMed indexed study

    PMID 37044210 from The Journal of nutrition.

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    120. Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.

    PUBMED • 2026 • PubMed indexed study

    PMID 41481605 from PloS one.

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    Open source
    121. Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review.

    PUBMED • 2023 • PubMed indexed study

    PMID 37146985 from Journal of sport rehabilitation.

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    122. Undenatured type II collagen for knee osteoarthritis.

    PUBMED • 2025 • PubMed indexed study

    PMID 40253594 from Annals of medicine.

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    Open source
    123. Urinary sulfated glycosaminoglycan insufficiency and chondroitin sulfate supplement in urolithiasis.

    PUBMED • 2019 • PubMed indexed study

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    Open source
    124. Basic Emollients for Xerosis Cutis Not Associated With Atopic Dermatitis: A Review of Clinical Studies.

    PUBMED • 2025 • PubMed indexed study

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    125. Synergistic effects of creatine supplementation and resistance training in the management of knee osteoarthritis: A narrative review.

    PUBMED • 2025 • PubMed indexed study

    PMID 41243927 from JPMA. The Journal of the Pakistan Medical Association.

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    126. Chondroitin Sulfate Enhances Proliferation and Migration via Inducing β-Catenin and Intracellular ROS as Well as Suppressing Metalloproteinases through Akt/NF-κB Pathway Inhibition in Human Chondrocytes.

    PUBMED • 2022 • PubMed indexed study

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    Open source
    127. Nutrition, osteoarthritis and cartilage metabolism.

    PUBMED • 2019 • PubMed indexed study

    PMID 30982220 from Aging clinical and experimental research.

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    128. Systemic drugs with impact on osteoarthritis.

    PUBMED • 2019 • PubMed indexed study

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    129. How to Treat Osteoarthritis in Obese Patients?

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    PMID 31241017 from Current rheumatology reviews.

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    130. EFFICACY OF HERBAL AND NATURALLY-DERIVED DIETARY SUPPLEMENTS FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS: A MINI-REVIEW.

    PUBMED • 2021 • PubMed indexed study

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    131. Noninterventional Therapies for the Management of Knee Osteoarthritis.

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    132. Natural Product Dietary Supplement Use by Individuals With Rheumatoid Arthritis: A Scoping Review.

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    133. Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy.

    PUBMED • 2019 • PubMed indexed study

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    134. GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.

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    135. Probiotics in human gut microbiota can degrade host glycosaminoglycans.

    PUBMED • 2018 • PubMed indexed study

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    136. Clinical Guide to Obesity and Nonherbal Nutraceuticals in Canine Orthopedic Conditions.

    PUBMED • 2022 • PubMed indexed study

    PMID 35562213 from The Veterinary clinics of North America. Small animal practice.

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    137. Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment.

    PUBMED • 2021 • PubMed indexed study

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    138. Oligodendrocyte precursor cells synthesize neuromodulatory factors.

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    139. Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study.

    PUBMED • 2018 • PubMed indexed study

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    Open source
    140. Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane.

    PUBMED • 2023 • PubMed indexed study

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    Open source
    141. Glucosamine and Chondroitin Sulfate: What Has Been Learned Since the Glucosamine/chondroitin Arthritis Intervention Trial.

    PUBMED • 2018 • PubMed indexed study

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    142. Chondroitin sulphate: a focus on osteoarthritis.

    PUBMED • 2016 • PubMed indexed study

    PMID 27194526 from Glycoconjugate journal.

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    143. Drugs for osteoarthritis.

    PUBMED • 2014 • PubMed indexed study

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    144. Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules.

    PUBMED • 2014 • PubMed indexed study

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    145. Natural Products for Promoting Joint Health and Managing Osteoarthritis.

    PUBMED • 2018 • PubMed indexed study

    PMID 30232562 from Current rheumatology reports.

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    Open source
    146. Preventing urinary tract infections after menopause without antibiotics.

    PUBMED • 2017 • PubMed indexed study

    PMID 28364867 from Maturitas.

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    147. Non-surgical treatments for the management of early osteoarthritis.

    PUBMED • 2016 • PubMed indexed study

    PMID 27043347 from Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.

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    148. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis.

    PUBMED • 2014 • PubMed indexed study

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    149. Evidence-Based Evaluation of Complementary Health Approaches for Pain Management in the United States.

    PUBMED • 2016 • PubMed indexed study

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    150. Managing the pain of knee osteoarthritis.

    PUBMED • 2014 • PubMed indexed study

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    151. Complementary and alternative medicine use in dermatology in the United States.

    PUBMED • 2014 • PubMed indexed study

    PMID 24517329 from Journal of alternative and complementary medicine (New York, N.Y.).

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    152. Dietary interventions for atopic disorders.

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    153. Inappropriate claims from non-equivalent medications in osteoarthritis: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

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    154. Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility?

    PUBMED • 2024 • PubMed indexed study

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    155. Osteoarthritis: diagnosis and treatment.

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    156. Glucosamine.

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    Open source
    157. Glucosamine and chondroitin sulfate.

    PUBMED • 2011 • PubMed indexed study

    PMID 21220090 from Rheumatic diseases clinics of North America.

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    158. Dietary supplements for osteoarthritis.

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    159. Nutrition and dietary supplements.

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    160. Nutripharmaceuticals for osteoarthritis.

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    161. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis.

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    162. Recent advances in glucosamine and chondroitin supplementation.

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    PMID 15553585 from The journal of knee surgery.

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    Open source
    163. Advances in corneal preservation.

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    164. Chondroitin and glucosamine in the management of osteoarthritis: an update.

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    165. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.

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    166. Use of glucosamine and chondroitin in persons with osteoarthritis.

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    167. Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp.

    PUBMED • 2020 • PubMed indexed study

    PMID 33055203 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

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    168. Dietary and viscosupplementation in ankle arthritis.

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    169. Risk assessment for glucosamine and chondroitin sulfate.

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    170. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence?

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    171. Glucosamine and chondroitin for osteoarthritis.

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    PMID 19094424 from The Journal of international medical research.

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    172. Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique.

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    174. The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals?

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    PMID 16170388 from Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

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    175. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease.

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    176. What about supplements for osteoarthritis? A critical and evidenced-based review.

    PUBMED • 2011 • PubMed indexed study

    PMID 21518314 from International journal of rheumatic diseases.

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    177. Sulfur in human nutrition and applications in medicine.

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    179. Chondroprotective agents: glucosamine and chondroitin.

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    180. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity.

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    181. Prevention of recurrent urinary tract infections in women.

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    182. Nutritional factors and osteoarthritis: recent developments.

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    183. Herbs and dietary supplement use in patients with stage 5 chronic kidney disease.

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    PMID 16538934 from Nephrology nursing journal : journal of the American Nephrology Nurses' Association.

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    185. Supplemental conditionally essential nutrients in cardiovascular disease therapy.

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    186. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis.

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    187. Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews.

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    188. Complementary and alternative modalities to relieve osteoarthritis symptoms.

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    189. Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis.

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    190. Alternative therapies for traditional disease states: osteoarthritis.

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    196. Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people.

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    199. Structural modulation of gut microbiota by chondroitin sulfate and its oligosaccharide.

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    200. Glucosamine and Chondroitin Use and Mortality Among Adults in the United States from 1999 to 2014.

    PUBMED • 2023 • PubMed indexed study

    PMID 36971848 from Journal of integrative and complementary medicine.

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    201. Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP.

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    202. Specialty supplement use and biologic measures of oxidative stress and DNA damage.

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    PMID 23917455 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

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    PUBMED • 2026 • PubMed indexed study

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    205. Interventions to improve locomotive syndrome: a systematic review and meta-analysis of randomized controlled trials.

    META_ANALYSIS • 2023 • PubMed indexed study

    PMID 37346825 from Nagoya journal of medical science.

    Outcome: Study design: META_ANALYSIS. Quality score: 10.0/10.[1342,1359,1360, etc.]

    Open source
    206. Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.

    RCT • 2019 • PubMed indexed study

    PMID 31257264 from Journal of nutritional science and vitaminology.

    Outcome: Study design: RCT. Quality score: 10.0/10.[1342,1359,1360, etc.]

    Open source
    207. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.

    RCT • 2021 • PubMed indexed study

    PMID 32981536 from The British journal of nutrition.

    Outcome: Study design: RCT. Quality score: 10.0/10.[1342,1359,1360, etc.]

    Open source
    208. A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study.

    RCT • 2024 • PubMed indexed study

    PMID 39203831 from Nutrients.

    Outcome: Study design: RCT. Quality score: 9.9/10.[1342,1359,1360, etc.]

    Open source
    209. Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review.

    SYSTEMATIC_REVIEW • 2023 • PubMed indexed study

    PMID 36902359 from International journal of molecular sciences.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.8/10.[1342,1359,1360, etc.]

    Open source
    210. Prevalence of Glucosamine and Omega-3 Fatty Acid Use and Characteristics of Users among Mid-Age Women: Analysis of a Nationally Representative Sample of 10,638 Women.

    RCT • 2016 • PubMed indexed study

    PMID 27273353 from The journal of nutrition, health & aging.

    Outcome: Study design: RCT. Quality score: 9.7/10.[1342,1359,1360, etc.]

    Open source
    211. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.

    RCT • 2013 • PubMed indexed study

    PMID 24274358 from Nutrition journal.

    Outcome: Study design: RCT. Quality score: 9.6/10.[1342,1359,1360, etc.]

    Open source
    212. Effect of Polyglucosamine on Weight Loss and Metabolic Parameters in Overweight and Obesity: A Systemic Review and Meta-Analysis.

    META_ANALYSIS • 2020 • PubMed indexed study

    PMID 32784736 from Nutrients.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.5/10.[1342,1359,1360, etc.]

    Open source
    213. Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis.

    META_ANALYSIS • 2025 • PubMed indexed study

    PMID 40300556 from The Journal of international medical research.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.3/10.[1342,1359,1360, etc.]

    Open source
    214. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.

    RCT • 2002 • PubMed indexed study

    PMID 11934964 from Rheumatology (Oxford, England).

    Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]

    Open source
    215. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

    RCT • 2002 • PubMed indexed study

    PMID 12374520 from Archives of internal medicine.

    Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]

    Open source
    216. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.

    RCT • 2001 • PubMed indexed study

    PMID 11214126 from Lancet (London, England).

    Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]

    Open source
    217. Sulodexide for Diabetic-Induced Disabilities: A Systematic Review and Meta-Analysis.

    META_ANALYSIS • 2021 • PubMed indexed study

    PMID 33502688 from Advances in therapy.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1342,1359,1360, etc.]

    Open source
    218. Sulodexide for the Symptoms and Signs of Chronic Venous Disease: A Systematic Review and Meta-analysis.

    META_ANALYSIS • 2020 • PubMed indexed study

    PMID 31989486 from Advances in therapy.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1342,1359,1360, etc.]

    Open source
    219. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions.

    RCT • 2023 • PubMed indexed study

    PMID 36918892 from Nutrition journal.

    Outcome: Study design: RCT. Quality score: 9.1/10.[1342,1359,1360, etc.]

    Open source
    220. Does Salt Form Matter? A Pilot Randomized, Double-Blind, Crossover Pharmacokinetic Comparison of Crystalline and Regular Glucosamine Sulfate in Healthy Volunteers.

    RCT • 2025 • PubMed indexed study

    PMID 40806074 from Nutrients.

    Outcome: Study design: RCT. Quality score: 9.1/10.[1342,1359,1360, etc.]

    Open source
    221. Glucosamine supplementation after anterior cruciate ligament reconstruction in athletes: a randomized placebo-controlled trial.

    RCT • 2015 • PubMed indexed study

    PMID 25630243 from Research in sports medicine (Print).

    Outcome: Study design: RCT. Quality score: 9.0/10.[1342,1359,1360, etc.]

    Open source
    222. [Effect of dietary supplements and whey protein on muscle mass and strength of the operated limb after anterior cruciate ligament reconstruction: a systematic review].

    SYSTEMATIC_REVIEW • 2023 • PubMed indexed study

    PMID 37346024 from Voprosy pitaniia.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1342,1359,1360, etc.]

    Open source
    223. A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs.

    SYSTEMATIC_REVIEW • 2021 • PubMed indexed study

    PMID 33624893 from Phytotherapy research : PTR.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]

    Open source
    224. Conditional Recommendations for Specific Dietary Ingredients as an Approach to Chronic Musculoskeletal Pain: Evidence-Based Decision Aid for Health Care Providers, Participants, and Policy Makers.

    SYSTEMATIC_REVIEW • 2019 • PubMed indexed study

    PMID 30986301 from Pain medicine (Malden, Mass.).

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]

    Open source
    225. TAME trial: a multi-arm phase II randomised trial of four novel interventions for malnutrition enteropathy in Zambia and Zimbabwe - a study protocol.

    RCT • 2019 • PubMed indexed study

    PMID 31727642 from BMJ open.

    Outcome: Study design: RCT. Quality score: 8.7/10.[1342,1359,1360, etc.]

    Open source
    226. Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults.

    RCT • 2015 • PubMed indexed study

    PMID 24621069 from Nutritional neuroscience.

    Outcome: Study design: RCT. Quality score: 8.6/10.[1342,1359,1360, etc.]

    Open source
    227. Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review.

    SYSTEMATIC_REVIEW • 2018 • PubMed indexed study

    PMID 29446485 from Journal of oral rehabilitation.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1342,1359,1360, etc.]

    Open source
    228. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial.

    RCT • 2004 • PubMed indexed study

    PMID 15501201 from The American journal of medicine.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]

    Open source
    229. Amiprilose hydrochloride for rheumatoid arthritis.

    RCT • 1989 • PubMed indexed study

    PMID 2672925 from Annals of internal medicine.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]

    Open source
    230. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.

    RCT • 2010 • PubMed indexed study

    PMID 20606148 from JAMA.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]

    Open source
    231. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study.

    RCT • 2018 • PubMed indexed study

    PMID 30132529 from Molecular medicine reports.

    Outcome: Study design: RCT. Quality score: 8.4/10.[1342,1359,1360, etc.]

    Open source
    232. Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial.

    RCT • 2014 • PubMed indexed study

    PMID 24616448 from Arthritis & rheumatology (Hoboken, N.J.).

    Outcome: Study design: RCT. Quality score: 8.4/10.[1342,1359,1360, etc.]

    Open source
    233. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials.

    RCT • 2008 • PubMed indexed study

    PMID 17681803 from Osteoarthritis and cartilage.

    Outcome: Study design: RCT. Quality score: 8.3/10.[1342,1359,1360, etc.]

    Open source
    234. Association of Mucin-Degrading Gut Microbiota and Dietary Patterns with Colonic Transit Time in Constipation: A Secondary Analysis of a Randomized Clinical Trial.

    RCT • 2024 • PubMed indexed study

    PMID 39796573 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    235. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects.

    RCT • 2006 • PubMed indexed study

    PMID 17065354 from Diabetes.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    236. The effect of glucosamine supplementation on people experiencing regular knee pain.

    RCT • 2003 • PubMed indexed study

    PMID 12547742 from British journal of sports medicine.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    237. Effect of glycomacropeptide fractions on cholecystokinin and food intake.

    RCT • 2010 • PubMed indexed study

    PMID 20205966 from The British journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    238. The effect of glucosamine on Serum HDL cholesterol and apolipoprotein AI levels in people with diabetes.

    RCT • 2007 • PubMed indexed study

    PMID 17682119 from Diabetes care.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    239. The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics.

    RCT • 2002 • PubMed indexed study

    PMID 12190996 from Diabetes, obesity & metabolism.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    240. The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure.

    RCT • 1990 • PubMed indexed study

    PMID 2283638 from Journal of human hypertension.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    241. Post-prandial glycaemic reduction by an alpha-glucosidase inhibitor in type 2 diabetic patients with therapeutically attained basal normoglycaemia.

    RCT • 1991 • PubMed indexed study

    PMID 1842749 from Diabetes research (Edinburgh, Scotland).

    Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]

    Open source
    242. Impact of Glucosamine Supplementation on Gut Health.

    RCT • 2021 • PubMed indexed study

    PMID 34202877 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.0/10.[1342,1359,1360, etc.]

    Open source
    243. Impact of dietary supplementation of glycocalyx precursors on vascular function in type 2 diabetes.

    RCT • 2024 • PubMed indexed study

    PMID 39480270 from Journal of applied physiology (Bethesda, Md. : 1985).

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    244. Effects of 4-month treatment with glycocalyx dietary supplement on endothelial glycocalyx and vascular function after COVID-19 infection.

    RCT • 2025 • PubMed indexed study

    PMID 40270280 from European journal of clinical investigation.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    245. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial.

    RCT • 2008 • PubMed indexed study

    PMID 18279523 from Nutrition journal.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]

    Open source
    246. Sulodexide in the Treatment of Patients with Early Stages of COVID-19: A Randomized Controlled Trial.

    RCT • 2021 • PubMed indexed study

    PMID 33677827 from Thrombosis and haemostasis.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    247. Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial.

    RCT • 2020 • PubMed indexed study

    PMID 32444040 from Complementary therapies in medicine.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]

    Open source
    248. Effect of glucosamine on intraocular pressure: a randomized clinical trial.

    RCT • 2017 • PubMed indexed study

    PMID 27768119 from Eye (London, England).

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    249. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.

    RCT • 2016 • PubMed indexed study

    PMID 26684635 from International journal of immunopathology and pharmacology.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    250. Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.

    RCT • 2017 • PubMed indexed study

    PMID 27801550 from Molecular nutrition & food research.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    251. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.

    RCT • 2018 • PubMed indexed study

    PMID 28862770 from Oral diseases.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    252. A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.

    RCT • 2016 • PubMed indexed study

    PMID 27052991 from Trials.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]

    Open source
    253. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals.

    RCT • 2004 • PubMed indexed study

    PMID 15135147 from Osteoarthritis and cartilage.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    254. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis.

    RCT • 2001 • PubMed indexed study

    PMID 11432083 from The Journal of the American Osteopathic Association.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    255. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study.

    RCT • 2011 • PubMed indexed study

    PMID 22001199 from Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    256. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.

    RCT • 2009 • PubMed indexed study

    PMID 19756416 from Advances in therapy.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    257. A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis.

    RCT • 2012 • PubMed indexed study

    PMID 22577354 from TheScientificWorldJournal.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    258. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study.

    RCT • 2001 • PubMed indexed study

    PMID 12171689 from The Journal of dermatological treatment.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    259. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].

    RCT • 2007 • PubMed indexed study

    PMID 17974032 from BMC complementary and alternative medicine.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    260. No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial.

    RCT • 2012 • PubMed indexed study

    PMID 22900984 from Journal of negative results in biomedicine.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    261. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial.

    RCT • 2009 • PubMed indexed study

    PMID 18848470 from Osteoarthritis and cartilage.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    262. Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trial.

    RCT • 2010 • PubMed indexed study

    PMID 20152042 from Arthritis research & therapy.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    263. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles.

    RCT • 2013 • PubMed indexed study

    PMID 22821424 from Inflammopharmacology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    264. Effects of glucosamine administration on patients with rheumatoid arthritis.

    RCT • 2007 • PubMed indexed study

    PMID 16953394 from Rheumatology international.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    265. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.

    RCT • 2004 • PubMed indexed study

    PMID 15021442 from Menopause (New York, N.Y.).

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    266. Effect of treatment based on syndrome differentiation by Chinese medicine on post-traumatic elbow arthritis.

    RCT • 2010 • PubMed indexed study

    PMID 20694783 from Chinese journal of integrative medicine.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    267. Clinical efficacy and safety of Gubitong Recipe () in treating osteoarthritis of knee joint.

    RCT • 2009 • PubMed indexed study

    PMID 20082253 from Chinese journal of integrative medicine.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    268. [Use of the immunopotentiator N-acetyl-glucosamine-N-acetylmuramyl dipeptide during triple anti-Helicobacter pylori therapy].

    RCT • 2012 • PubMed indexed study

    PMID 23479993 from Terapevticheskii arkhiv.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    269. Postprandial glycemic control, hormonal effects and carbohydrate malabsorption during long-term administration of the alpha-glucosidase inhibitor miglitol.

    RCT • 1990 • PubMed indexed study

    PMID 2292349 from Digestion.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]

    Open source
    270. No Associations Between Glucosamine Supplementation and Dementia or Parkinson's Disease: Findings From a Large Prospective Cohort Study.

    COHORT • 2024 • PubMed indexed study

    PMID 37158699 from The journals of gerontology. Series A, Biological sciences and medical sciences.

    Outcome: Study design: COHORT. Quality score: 6.8/10.[1342,1359,1360, etc.]

    Open source
    271. Association between glucosamine use and albuminuria in the UK: a cohort and Mendelian randomisation study.

    COHORT • 2025 • PubMed indexed study

    PMID 41271412 from BMJ open.

    Outcome: Study design: COHORT. Quality score: 6.8/10.[1342,1359,1360, etc.]

    Open source
    272. Variation in Plasma Levels of Glucosamine With Chronic Dosing: A Possible Reason for Inconsistent Clinical Outcomes in Osteoarthritis.

    RCT • 2020 • PubMed indexed study

    PMID 32713600 from Clinical therapeutics.

    Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.7/10.[1342,1359,1360, etc.]

    Open source
    273. Complementary medicine use and its cost in Australians with type 2 diabetes: the Fremantle Diabetes Study Phase II.

    RCT • 2020 • PubMed indexed study

    PMID 31314167 from Internal medicine journal.

    Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.7/10.[1342,1359,1360, etc.]

    Open source
    274. Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study.

    COHORT • 2025 • PubMed indexed study

    PMID 40437330 from European journal of nutrition.

    Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]

    Open source
    275. Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank.

    COHORT • 2025 • PubMed indexed study

    PMID 40169583 from Nutrition & diabetes.

    Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]

    Open source
    276. The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.

    COHORT • 2021 • PubMed indexed study

    PMID 34010361 from PloS one.

    Outcome: Study design: COHORT. Quality score: 6.3/10.[1342,1359,1360, etc.]

    Open source
    277. Patterns of dietary supplement use among older men and women in the UK: findings from the Hertfordshire Cohort Study.

    COHORT • 2012 • PubMed indexed study

    PMID 22499447 from The journal of nutrition, health & aging.

    Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]

    Open source
    278. Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort.

    COHORT • 2023 • PubMed indexed study

    PMID 36716122 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

    Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]

    Open source
    279. Glucosamine Use Is Associated with a Higher Risk of Cardiovascular Diseases in Patients with Osteoarthritis: Results from a Large Study in 685,778 Subjects.

    PUBMED • 2022 • PubMed indexed study

    PMID 36145069 from Nutrients.

    Outcome: Study design: OTHER. Quality score: 6.0/10.[1342,1359,1360, etc.]

    Open source
    280. Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study.

    COHORT • 2025 • PubMed indexed study

    PMID 40879960 from Aging clinical and experimental research.

    Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]

    Open source
    281. Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis.

    COHORT • 2023 • PubMed indexed study

    PMID 37422736 from Mayo Clinic proceedings.

    Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]

    Open source
    282. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.

    COHORT • 2020 • PubMed indexed study

    PMID 32253185 from Annals of the rheumatic diseases.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    283. Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy.

    PUBMED • 2022 • PubMed indexed study

    PMID 35216170 from International journal of molecular sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    284. Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study.

    COHORT • 2022 • PubMed indexed study

    PMID 36175979 from Biology of sex differences.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    285. Assessment of pharmacy students' knowledge, attitude, and practice toward herbal dietary supplements.

    COHORT • 2022 • PubMed indexed study

    PMID 33048645 from Journal of American college health : J of ACH.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    286. Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass.

    PUBMED • 2022 • PubMed indexed study

    PMID 35563167 from International journal of molecular sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    287. The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study.

    COHORT • 2022 • PubMed indexed study

    PMID 36514123 from Alzheimer's research & therapy.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    288. Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components.

    COHORT • 2020 • PubMed indexed study

    PMID 33030036 from Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    289. Recurrent retinal vein thrombosis: prevention with Aspirin, Pycnogenol®, ticlopidine, or sulodexide.

    COHORT • 2019 • PubMed indexed study

    PMID 30964246 from Minerva cardioangiologica.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]

    Open source
    290. Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort.

    COHORT • 2018 • PubMed indexed study

    PMID 29411204 from Cancer causes & control : CCC.

    Outcome: Study design: COHORT. Quality score: 5.6/10.[1342,1359,1360, etc.]

    Open source
    291. Self-reported medication and herb/supplement use by women with and without fibromyalgia.

    COHORT • 2009 • PubMed indexed study

    PMID 19445618 from Journal of women's health (2002).

    Outcome: Study design: COHORT. Quality score: 5.5/10.[1342,1359,1360, etc.]

    Open source
    292. Sweet solution: sugars to the rescue.

    PUBMED • 2002 • PubMed indexed study

    PMID 12186848 from The Journal of cell biology.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1342,1359,1360, etc.]

    Open source
    293. Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.

    PUBMED • 2024 • PubMed indexed study

    PMID 38225221 from Cell death & disease.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    294. Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells.

    PUBMED • 2024 • PubMed indexed study

    PMID 38732122 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    295. GlcNac produced by the gut microbiome enhances host influenza resistance by modulating NK cells.

    PUBMED • 2023 • PubMed indexed study

    PMID 37953509 from Gut microbes.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    296. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study.

    COHORT • 2007 • PubMed indexed study

    PMID 17958896 from Nutrition journal.

    Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    297. Plasma Glutaminyl-Peptide Cyclotransferase Mediates Glucosamine-Metabolism-Driven Protection Against Hypertension: A Mendelian Randomization Study.

    PUBMED • 2024 • PubMed indexed study

    PMID 39596173 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    298. Effects of Modified Glucosamine on the Chondrogenic Potential of Circulating Stem Cells under Experimental Inflammation.

    PUBMED • 2023 • PubMed indexed study

    PMID 37373540 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    299. Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients' serum after SARS-CoV-2 infection.

    PUBMED • 2023 • PubMed indexed study

    PMID 38188630 from Frontiers in cellular and infection microbiology.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    300. Genomic, probiotic, and metabolic potentials of Liquorilactobacillus nagelii AGA58, a novel bacteriocinogenic motile strain isolated from lactic acid-fermented shalgam.

    PUBMED • 2023 • PubMed indexed study

    PMID 36384719 from Journal of bioscience and bioengineering.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]

    Open source
    301. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank.

    PUBMED • 2019 • PubMed indexed study

    PMID 31088786 from BMJ (Clinical research ed.).

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    302. The effect of glucosamine and glucosamine caramel on quality and consumer acceptability of regular and reduced salt breakfast sausages.

    PUBMED • 2021 • PubMed indexed study

    PMID 32980721 from Meat science.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    303. A LC-MS/MS method to simultaneously profile 14 free monosaccharides in biofluids.

    PUBMED • 2022 • PubMed indexed study

    PMID 35114473 from Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    304. Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritional Supplements of Cancer Adjuvant Therapy.

    PUBMED • 2019 • PubMed indexed study

    PMID 30791594 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    305. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses.

    PUBMED • 2019 • PubMed indexed study

    PMID 31461653 from Cell reports.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    306. Study of the Pollen Grain Metabolome under Deposition of Nitrogen and Phosphorus in Taxus baccata L. and Juniperus communis L.

    PUBMED • 2022 • PubMed indexed study

    PMID 36430583 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]

    Open source
    307. Optimizing the Preoperative Preparation of Sarcopenic Older People: The Role of Prehabilitation and Nutritional Supplementation before Knee Arthroplasty.

    PUBMED • 2024 • PubMed indexed study

    PMID 39458460 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    308. A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.

    PUBMED • 2011 • PubMed indexed study

    PMID 21218504 from Diabetes/metabolism research and reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    309. Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights.

    PUBMED • 2024 • PubMed indexed study

    PMID 39275184 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    310. Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action.

    PUBMED • 2001 • PubMed indexed study

    PMID 11533317 from The Journal of nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    311. Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey.

    COHORT • 2018 • PubMed indexed study

    PMID 30249608 from The British journal of general practice : the journal of the Royal College of General Practitioners.

    Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    312. Sulodexide Slows Down the Senescence of Aortic Endothelial Cells Exposed to Serum from Patients with Peripheral Artery Diseases.

    PUBMED • 2018 • PubMed indexed study

    PMID 29587258 from Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

    Outcome: Study design: OTHER. Quality score: 5.1/10.[1342,1359,1360, etc.]

    Open source
    313. Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration.

    PUBMED • 2022 • PubMed indexed study

    PMID 35565950 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]

    Open source
    314. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review.

    PUBMED • 2020 • PubMed indexed study

    PMID 32878230 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]

    Open source
    315. Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond.

    PUBMED • 2020 • PubMed indexed study

    PMID 33375692 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]

    Open source
    316. Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities.

    PUBMED • 2025 • PubMed indexed study

    PMID 40020645 from Clinical nutrition (Edinburgh, Scotland).

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]

    Open source
    317. Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity.

    PUBMED • 2025 • PubMed indexed study

    PMID 40240774 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]

    Open source
    318. Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity.

    PUBMED • 2024 • PubMed indexed study

    PMID 39247955 from Hypertension (Dallas, Tex. : 1979).

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]

    Open source
    319. Metabolic brain imaging with glucosamine CEST MRI: in vivo characterization and first insights.

    PUBMED • 2023 • PubMed indexed study

    PMID 38086821 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]

    Open source
    320. There seems to be similar improvement in pain and mouth opening limitation when comparing glucosamine supplements with a placebo or ibuprofen in patients with temporomandibular joint osteoarthritis.

    PUBMED • 2018 • PubMed indexed study

    PMID 29801932 from Journal of the American Dental Association (1939).

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]

    Open source
    321. Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.

    PUBMED • 2023 • PubMed indexed study

    PMID 37932498 from Molecular biology reports.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    322. Glucosamine and lower mortality and cancer incidence: Selection bias in the observational studies.

    PUBMED • 2022 • PubMed indexed study

    PMID 36029480 from Pharmacoepidemiology and drug safety.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    323. Effects of Glucosamine in the Temporomandibular Joint Osteoarthritis: A Review.

    PUBMED • 2024 • PubMed indexed study

    PMID 38213156 from Current rheumatology reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    324. Biological activities of glucosamine and its related substances.

    PUBMED • 2012 • PubMed indexed study

    PMID 22361198 from Advances in food and nutrition research.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    325. Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank.

    PUBMED • 2020 • PubMed indexed study

    PMID 31988063 from Diabetes care.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    326. A review on the biological activities and the nutraceutical potential of chitooligosaccharides.

    PUBMED • 2025 • PubMed indexed study

    PMID 39637700 from Carbohydrate research.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    327. Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome.

    PUBMED • 2019 • PubMed indexed study

    PMID 30944389 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    328. Enhanced Antiarthritic Efficacy by Nanoparticles of (-)-Epigallocatechin Gallate-Glucosamine-Casein.

    PUBMED • 2019 • PubMed indexed study

    PMID 31117504 from Journal of agricultural and food chemistry.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    329. Sulodexide reduces glucose induced senescence in human retinal endothelial cells.

    PUBMED • 2021 • PubMed indexed study

    PMID 34075143 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]

    Open source
    330. Protein.

    PUBMED • 2018 • PubMed indexed study

    PMID 30060014 from Advances in nutrition (Bethesda, Md.).

    Outcome: Study design: OTHER. Quality score: 4.7/10.[1342,1359,1360, etc.]

    Open source