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Supplement

Gotu Kola (Centella asiatica)

Triterpenoid saponins (asiaticoside, madecassoside) promote collagen synthesis, increase GABA and acetylcholine, enhance BDNF expression, strengthen venous walls, and modulate cortisol.[1356,1686,1688, etc.]

Superscript reference numbers link to the Sources bibliography.

Moderate Evidence

CognitiveSkin HairStress ResilienceMobilityalias: Centella asiaticaalias: Indian pennywortalias: brahmi (Ayurvedic)

Composite Rating

2.4/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

46/100

Moderate depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Minimal

Safety Friction

88/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 7 • mentions 8 • links 20

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Cognitive, Skin Hair, Stress Resilience, Mobility.[513,661,885, etc.]

Dose guide: Human-study daily dose: 68 mg-160 mg/day (moderate-confidence extraction from PubMed abstracts)..[513,661,885, etc.]

Category: botanical.[513,661,885, etc.]

At-A-Glance Evidence Architecture[1356,1686,1688, etc.]

Clinical Depth

Humans: 7 • RCTs: 3 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 14 • Interactions: 9

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

Established

Trend

→ Stable evidence base

Depth

13 total studies

Timeline

19992021

Top Signal Metrics[1356,1686,1688, etc.]

In vitro / tissue

Safety adverse signals

Total indexed

Animal-only studies

Interaction signals

Human studies

Community Direction Mix[513,661,885, etc.]

Weighted direction score: 9 (Mixed / Neutral)

Benefit4 (50%)

Evidence Quality Summary[1356,1686,1688, etc.]

Some human evidence or substantial animal evidence.

In vitro / tissue

Safety adverse signals

Total indexed

Animal-only studies

Interaction signals

Human studies

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b3

Human Studies (other)Level 3-44

All IndexedAll levels13

Evidence Strength: Moderate

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1356,1686,1688, etc.]

PMID 30456780 • 2019 Aug

Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females.

Journal of cosmetic dermatology

Open PubMed

PMID 17324660 • 2007 Mar

Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults.

Journal of the American Dietetic Association

Open PubMed

PMID 16729760 • 2006

Community Report Frequency[513,661,885, etc.]

Benefit reports: 4

Adverse reports: 3

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[513,661,885, etc.]

Benefits

Memory enhancement (learning and retention): 1
Cognitive function improvement: 1
Anxiety reduction: 1
Neuroprotection: 1
Attention improvement: 1

Adverse

Those wanting immediate effects: 1
GI-sensitive individuals: 1

No Effect

insufficient no-effect reports captured: 0

Classic Ayurvedic brain and skin herb. Best evidence for chronic venous insufficiency and wound healing. Also shows cognitive and anxiolytic promise. | Step2: Insufficient empirical signal for a directional adjustment.

Community Evidence Examples[513,661,885, etc.]

aggregate • benefit

Aggregate community signal: 8 directional mentions (benefit 4, adverse 3, no-effect 0, mixed 1).

Open mention

Retail Signal Examples

amazon

Amazon search for Gotu Kola (Centella asiatica)

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1356,1686,1688, etc.]

1. Centella asiatica and cognitive function: systematic review

SYSTEMATIC_REVIEW • 2017 • Adults

8 studies with 320 subjects.

Outcome: Gotu kola improved working memory, attention, and mood (reduced anxiety) in elderly and healthy adults; asiaticoside may enhance hippocampal neurogenesis.[1356,1686,1688, etc.]

Open source

2. Centella asiatica for chronic venous insufficiency: MA of 8 RCTs

META_ANALYSIS • 2013 • Adults

8 RCTs with 498 CVI patients.

Outcome: TTFCA (60-120 mg/day) significantly improved leg heaviness, edema, and venous distensibility in chronic venous insufficiency.[1356,1686,, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[1356,1686,1688, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1356,1686,1688, etc.]

Community Direction Mix[513,661,885, etc.]

Evidence Quality Summary[1356,1686,1688, etc.]

Study Type Breakdown

Top Human Studies[1356,1686,1688, etc.]

Community Report Frequency[513,661,885, etc.]

Top Reported Effects[513,661,885, etc.]

Community Evidence Examples[513,661,885, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1356,1686,1688, etc.]

Safety and Pitfalls