Session check

Supplement

Green Tea Extract (EGCG)

EGCG inhibits COMT (increasing catecholamines), activates AMPK, enhances thermogenesis, provides potent antioxidant activity, and crosses BBB for neuroprotection.[1319,1344,1346, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Fat LossLongevityCognitiveHeart HealthInflammationalias: EGCGalias: epigallocatechin gallatealias: matcha extractalias: Camellia sinensis extract

Composite Rating

3.8/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Minimal

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 8 • links 212

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Fat Loss, Longevity, Cognitive, Heart Health, Inflammation.[516,664,888, etc.]

Dose guide: Human-study daily dose: 456 mg-800 mg/day (higher-confidence extraction from PubMed abstracts)..[516,664,888, etc.]

Category: botanical.[516,664,888, etc.]

At-A-Glance Evidence Architecture[1319,1344,1346, etc.]

Clinical Depth

Humans: 270 • RCTs: 86 • Meta: 13

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 241 • Interactions: 163

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

↑ Growing evidence base

Depth

554 total studies · 24 recent

Timeline

19982026

Top Signal Metrics[1319,1344,1346, etc.]

Total indexed

554

Animal-only studies

553

In vitro / tissue

393

Human studies

270

Safety adverse signals

241

Interaction signals

163

Community Direction Mix[516,664,888, etc.]

Weighted direction score: 9 (Mixed / Neutral)

Benefit

Evidence Quality Summary[1319,1344,1346, etc.]

≥2 meta-analyses OR (≥5 RCTs AND ≥25 human studies).

Total indexed

554

Animal-only studies

553

In vitro / tissue

393

Human studies

270

Safety adverse signals

241

Interaction signals

163

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a13

Randomized TrialsLevel 1b86

Human Studies (other)Level 3-4171

All IndexedAll levels554

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1319,1344,1346, etc.]

PMID 32118296 • 2020 Mar 2

Green tea (Camellia sinensis) for the prevention of cancer.

The Cochrane database of systematic reviews

Open PubMed

PMID 26093535 • 2016 Jun

Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial.

Clinical nutrition (Edinburgh, Scotland)

Open PubMed

PMID 31084381 • 2019 Dec

Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial.

Community Report Frequency[516,664,888, etc.]

Benefit reports: 4

Adverse reports: 3

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[516,664,888, etc.]

Benefits

Fat oxidation and metabolism boost: 1
Antioxidant protection: 1
Cancer prevention potential: 1
Cardiovascular protection: 1
Cognitive function support: 1
Blood sugar regulation: 1

Adverse

Liver disease: 1
Taking high doses on empty stomach: 1
Iron deficiency: 1

No Effect

insufficient no-effect reports captured: 0

One of the best-supported natural fat-loss aids. Take with food — not fasted — for liver safety. | Step2: Insufficient empirical signal for a directional adjustment.

Community Evidence Examples[516,664,888, etc.]

aggregate • benefit

Aggregate community signal: 8 directional mentions (benefit 4, adverse 3, no-effect 0, mixed 1).

Open mention

Retail Signal Examples

amazon

Amazon search for Green Tea Extract (EGCG)

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1319,1344,1346, etc.]

1. Green tea catechins and body weight: MA of 15 RCTs

META_ANALYSIS • 2015 • Adults

15 RCTs with 1243 subjects.

Outcome: GTE with caffeine significantly reduced body weight (−1.38 kg), waist circumference, and body fat vs placebo over 12+ weeks.[1319,1344,1346, etc.]

Open source

2. Green tea and cardiovascular risk: MA of prospective studies

META_ANALYSIS • 2011 • Adults

13 studies with 283,622 subjects.

Outcome: Drinking 3+ cups/day (equivalent to ~300 mg catechins) reduced CVD mortality (RR 0.74) and stroke risk (RR 0.80).[1319,1344,1346, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[1319,1344,1346, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1319,1344,1346, etc.]

Community Direction Mix[516,664,888, etc.]

Evidence Quality Summary[1319,1344,1346, etc.]

Study Type Breakdown

Top Human Studies[1319,1344,1346, etc.]

Community Report Frequency[516,664,888, etc.]

Top Reported Effects[516,664,888, etc.]

Community Evidence Examples[516,664,888, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1319,1344,1346, etc.]

Safety and Pitfalls