Supplement
Mushroom with neurotrophic signaling potential.[3044,3658,4926, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
34/100
Early depth from human/RCT/meta counts
Community Direction
-6
Mixed / Neutral • confidence Minimal
Safety Friction
84/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 6 • mentions 5 • links 16
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Focus, Longevity, Stress Resilience.[552,700,924, etc.]
Dose guide: Human-study daily dose: 1800 mg/day (early-confidence extraction from PubMed abstracts)..[552,700,924, etc.]
Category
Botanical
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 1800 mg/day (early-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 1800 mg/day (early-confidence extraction from PubMed abstracts).[3044,, etc.]
Clinical Depth
Humans: 6 • RCTs: 1 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 12 • Interactions: 8
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
30 total studies · 2 recent
Timeline
Total indexed
30
Animal-only studies
23
In vitro / tissue
18
Safety adverse signals
12
Interaction signals
8
Human studies
6
Weighted direction score: -6 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Total indexed
30
Animal-only studies
23
In vitro / tissue
18
Safety adverse signals
12
Interaction signals
8
Human studies
6
Randomized trials
1
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 38004235 • 2023 Nov 20
The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study.
Nutrients
Open PubMedPMID 37603263 • 2023 Sep
Over the Counter Supplements for Memory: A Review of Available Evidence.
CNS Drugs
Open PubMedPMID 38246232 • 2024 Mar
A review of the effects of mushrooms on mood and neurocognitive health across the lifespan.
Neurosci Biobehav Rev
Open PubMedBenefit reports: 2
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Response variability appears high in user reports. | Step2: Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
aggregate • unclear
Aggregate community signal: 5 directional mentions (benefit 2, adverse 2, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Lion's Mane
Rating: n/a | Reviews: n/a
Open productEvidence Sources
RCT • 2020 • Adults
Small studies with short follow-up.
Outcome: Signal for mild cognitive and mood support.[3044,3658,4926, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 6, RCTs 1, meta-analyses 0.[3044,3658,4926, etc.]
Open sourcePMID 29953363 • 2018
Dietary Supplementation of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice.
Int J Med Mushrooms
Open PubMedPMID 39988819 • 2025 Dec
Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.
Nutr Res Rev
Open PubMedPMID 32563801 • 2020 Nov 30
Selenium biofortification in Hericium erinaceus (Lion's Mane mushroom) and its in vitro bioaccessibility.
Food Chem
Open PubMedGNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22lion's%20mane%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22lion's%20mane%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=lion's%20mane
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 1800 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (manual mapping confidence 1.00).
Imported legacy monthly cost signal: ~$25.00.
Legacy community note: Beloved in nootropic and health communities. Users report improved focus, mental clarity, and reduced brain fog. Some note itchy skin initially (NGF-related). Dual extract (hot water + alcohol) strongly preferred.
Community Sources
PUBMED • 2023 • Human evidence curation set
PMID 38004235 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37603263 from CNS Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38246232 from Neurosci Biobehav Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29953363 from Int J Med Mushrooms.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39988819 from Nutr Res Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32563801 from Food Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[3044,3658,4926, etc.]
Open source