Supplement
Supports broad cellular function with category-specific mechanisms.[1854,1975,2150, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
24/100
Early depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 6 • mentions 2 • links 16
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FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Goal alignment: Longevity, Metabolic Health, Energy.[590,738,962, etc.]
Dose guide: Human-study daily dose: 1300 mg/day (moderate-confidence extraction from PubMed abstracts)..[590,738,962, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 1300 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 1300 mg/day (moderate-confidence extraction from PubMed abstracts).[1854,, etc.]
Clinical Depth
Humans: 6 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 23 • Interactions: 15
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
53 total studies
Timeline
Animal-only studies
62
Total indexed
53
In vitro / tissue
49
Safety adverse signals
23
Interaction signals
15
Human studies
6
Weighted direction score: 0 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Animal-only studies
62
Total indexed
53
In vitro / tissue
49
Safety adverse signals
23
Interaction signals
15
Human studies
6
Randomized trials
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 32461309 • 2020 Jul 16
Oregano Oil and Its Principal Component, Carvacrol, Inhibit HIV-1 Fusion into Target Cells.
J Virol
Open PubMedPMID 30225247 • 2018
Protective Effects of Benzoic Acid, Bacillus Coagulans, and Oregano Oil on Intestinal Injury Caused by Enterotoxigenic Escherichia coli in Weaned Piglets.
Biomed Res Int
Open PubMedPMID 20492179 • 2010 Jan-Feb
Thermal inactivation and postthermal treatment growth during storage of multiple Salmonella serotypes in ground beef as affected by sodium lactate and oregano oil.
Benefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22oregano%20oil%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Oregano Oil
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 6, RCTs 0, meta-analyses 0.[1854,1975,2150, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32461309 from J Virol.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,, etc.]
J Food Sci
PMID 18676709 • 2008 Oct
Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.
Appl Environ Microbiol
Open PubMedPMID 30839090 • 2019 Jul 1
Mexican oregano essential oils given in drinking water on performance, carcass traits, and meat quality of broilers.
Poult Sci
Open PubMedPMID 23127706 • 2012 Nov
Effect of organic acids on Salmonella colonization and shedding in weaned piglets in a seeder model.
J Food Prot
Open PubMedFallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22oregano%20oil%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=oregano%20oil
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 1300 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
Community Sources
PUBMED • 2018 • Human evidence curation set
PMID 30225247 from Biomed Res Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,1975,2150, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20492179 from J Food Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,1975,2150, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18676709 from Appl Environ Microbiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,1975,2150, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30839090 from Poult Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,1975,2150, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 23127706 from J Food Prot.
Outcome: See linked PubMed abstract for methods and outcomes.[1854,1975,2150, etc.]
Open source