Supplement
Supports broad cellular function with category-specific mechanisms.[1638,1787,2004, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
41/100
Early depth from human/RCT/meta counts
Community Direction
-9
Mixed / Neutral • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 14 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[379,381,443, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[379,381,443, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 12 • RCTs: 1 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 21 • Interactions: 17
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
19 total studies · 3 recent
Timeline
Safety adverse signals
21
Total indexed
19
Interaction signals
17
Animal-only studies
16
Human studies
12
In vitro / tissue
12
Weighted direction score: -9 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Safety adverse signals
21
Total indexed
19
Interaction signals
17
Animal-only studies
16
Human studies
12
In vitro / tissue
12
Randomized trials
1
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 35875924 • 2022 Nov
The chronic effects of a combination of herbal extracts (Euphytose(®)) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans.
J Psychopharmacol
Open PubMedPMID 22472025 • 2012 Aug
Nutraceuticals in psychiatric practice.
Recent Pat CNS Drug Discov
Open PubMedPMID 36048322 • 2022 Oct
Nip it in the Bud: Botanicals for Anxiety - a Practical Prescriber's Guide.
Curr Psychiatry Rep
Open PubMedBenefit reports: 5
Adverse reports: 5
No-effect reports: 0
Mixed reports: 4
Unclear reports: 0
Signal confidence: 0.59
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 8 mentions (confidence 0.59) across alcoholicsanonymous, sleep, TwoXPreppers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
post • r/alcoholicsanonymous • benefit
My sponsor told me if I don’t quit ashwagandha- she’s dropping me I am just over 100 days clean and sober. 4 weeks ago I asked a woman I heard speak at a meeting if she would be my sponsor. She said yes and we’ve met up to read the big boo…
Open mentionpost • r/sleep • mixed
Best natural sleep supplement you've tried? I've tried valerian root, passionflower, magnesium powder, zinc and melatonin. All of which had a negligible effect. I'm sceptical that these natural supplements actually work and perhaps only wo…
Open mentionpost • r/TwoXPreppers • mixed
Herbs aren’t a good replacement for medicine, but… Sometimes ya gotta use what you got. After 40+ years of struggling with depression and ADHD, I have a bunch of anecdotally effective food supplements and herbs to keep my brain mostly func…
amazon
Amazon search for Passionflower
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 12, RCTs 1, meta-analyses 0.[1638,1787,2004, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35875924 from J Psychopharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.
PMID 40054227 • 2025 May
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Sleep Med
Open PubMedPMID 17853630 • 2007 Aug 15
Herbal and dietary supplements for treatment of anxiety disorders.
Am Fam Physician
Open PubMedPMID 15857218 • 2005 Spring
Passionflower fruit-a "new" source of lycopene?
J Med Food
Open PubMedPMID 20929532 • 2010 Oct 7
Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
Nutr J
Open PubMedPMID 40338321 • 2025 Oct
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
Naunyn Schmiedebergs Arch Pharmacol
Open PubMedPMID 40572610 • 2025 Jun 19
Validated UHPLC Methods for Melatonin Quantification Reveal Regulatory Violations in EU Online Dietary Supplements Commerce.
Molecules
Open PubMedterminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22passionflower%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • mixed
Which sleep supplements are underrated or relatively unknown? I think I have tried all the sleep supplements I have heard of by now. Some work very well: L Theanine, phosphatidylserine, lemon balm, skullcap, saffron, tart cherry Many do no…
Open mentionpost • r/herbalism • mixed
Best LEGAL herbs for anxiety? I live in a country where it's impossible to obtain illegal herbs like cannabis, kanna, kava, CBD oil... Etc. I took multiple SSRIs throughout my life and honestly I'm still suffering from the side effects (PS…
Open mentionpost • r/LucidDreaming • benefit
Effect of Valerian root on dreaming On and off through my years, I've experimented with different kinds of natural sleep aids like melatonin, magnesium, passionflower, camomille, and more. Also, at different periods of my life I've had som…
Open mentionpost • r/cfs • benefit
Some things that helped my recovery/long term remission TLDR: I was sick for about 15 years, with a swift initial decline, about ten years severe and then a slow ascent with setbacks. This began 20 years ago when we didn’t know about pacin…
Open mentionpost • r/herbalism • adverse
Passionflower side effects. Please help My naturopath recommended passionflower tea to help with severe gut issues and hypersensitivity. Symptoms like severe burping, gas, bloating, diarrhea, cramps. Everything seems to set me off far too …
Open mentionCommunity Sources
PUBMED • 2012 • Human evidence curation set
PMID 22472025 from Recent Pat CNS Drug Discov.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36048322 from Curr Psychiatry Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40054227 from Sleep Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17853630 from Am Fam Physician.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 15857218 from J Med Food.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20929532 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40338321 from Naunyn Schmiedebergs Arch Pharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40572610 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1638,1787,2004, etc.]
Open source