Supplement
Supports electrolyte balance, enzymatic activity, and metabolic signaling.[1633,1827,1855, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-20
Caution Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 3 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[606,753,979, etc.]
Dose guide: Human-study daily dose: 20 mg-500 mg/day (higher-confidence extraction from PubMed abstracts)..[606,753,979, etc.]
Category
Mineral
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 20 mg-500 mg/day (higher-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 20 mg-500 mg/day (higher-confidence extraction from PubMed abstracts).[,, etc.]
Clinical Depth
Humans: 189 • RCTs: 42 • Meta: 3
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 92 • Interactions: 38
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
269 total studies · 2 recent
Timeline
Total indexed
269
Human studies
189
Animal-only studies
119
Safety adverse signals
92
In vitro / tissue
45
Randomized trials
42
Weighted direction score: -20 (Caution Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
269
Human studies
189
Animal-only studies
119
Safety adverse signals
92
In vitro / tissue
45
Randomized trials
42
Interaction signals
38
Meta-analyses
3
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 27915395 • 2017 Oct
Effect of potassium citrate supplement on stone recurrence before or after lithotripsy: systematic review and meta-analysis.
Urolithiasis
Open PubMedPMID 25572045 • 2015 Apr
The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis.
Osteoporos Int
Open PubMedPMID 25454613 • 2015 Apr
Metabolic evaluation and recurrence prevention for urinary stone patients: EAU guidelines.
Eur Urol
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
aggregate • unclear
Aggregate community signal: 3 directional mentions (benefit 1, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Potassium Citrate
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 189, RCTs 42, meta-analyses 3.[1633,1827,1855, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27915395 from Urolithiasis.
Outcome: See linked PubMed abstract for methods and outcomes.[,, etc.]
PMID 40945526 • 2026 Jan
Rifasutenizol-based triple therapy versus bismuth plus clarithromycin-based triple therapy for first-line treatment of Helicobacter pylori infection in China (EVEREST-HP): a phase 3, multicentre, randomised, triple-dummy, double-blind, controlled, non-inferiority trial.
Lancet Infect Dis
Open PubMedPMID 18689384 • 2008 Aug
Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 37382933 • 2023 Oct 1
Kaliuresis and Intracellular Uptake of Potassium with Potassium Citrate and Potassium Chloride Supplements: A Randomized Controlled Trial.
Clin J Am Soc Nephrol
Open PubMedPMID 9255197 • 1997 Jul
Potassium intake and cardiovascular reactivity in children with risk factors for essential hypertension.
J Pediatr
Open PubMedPMID 38872014 • 2024 Nov
Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study.
Clin Exp Nephrol
Open PubMedPMID 15723964 • 2005 Apr
Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in hypertensives.
Hypertension
Open PubMedPMID 37057692 • 2023 Apr 3
Kidney stone disease.
Ugeskr Laeger
Open PubMedPMID 21751520 • 2011
[Hypercalciuria].
Przegl Lek
Open PubMedPMID 31895162 • 2020 Mar
Occupational kidney stones.
Curr Opin Nephrol Hypertens
Open PubMedPMID 30478476 • 2019 Feb
Empiric therapy for kidney stones.
Urolithiasis
Open PubMedPMID 327103 • 1977 Jul
Ureterosigmoidostomy.
J Urol
Open PubMedPMID 18273648 • 2009 Nov
Medical treatment of pediatric urolithiasis.
Pediatr Nephrol
Open PubMedterminated
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Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 20 mg-500 mg/day (confidence HIGH).
Extracted from 8 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$7.00.
Legacy community note: Often mentioned as important but underconsumed. Many prefer to increase through food (bananas, potatoes, leafy greens). Supplement regulation limits make large supplemental doses inconvenient.
Community Sources
PUBMED • 2015 • Human evidence curation set
PMID 25572045 from Osteoporos Int.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25454613 from Eur Urol.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 40945526 from Lancet Infect Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18689384 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37382933 from Clin J Am Soc Nephrol.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 1997 • Human evidence curation set
PMID 9255197 from J Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38872014 from Clin Exp Nephrol.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 15723964 from Hypertension.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37057692 from Ugeskr Laeger.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21751520 from Przegl Lek.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31895162 from Curr Opin Nephrol Hypertens.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30478476 from Urolithiasis.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 1977 • Human evidence curation set
PMID 327103 from J Urol.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 18273648 from Pediatr Nephrol.
Outcome: See linked PubMed abstract for methods and outcomes.[1633,1827,1855, etc.]
Open source