Supplement
Supports broad cellular function with category-specific mechanisms.[1707,3953,4907, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-2
Mixed / Neutral • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 13 • links 22
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[14,201,368, etc.]
Dose guide: Human-study daily dose: 200 mg/day (moderate-confidence extraction from PubMed abstracts)..[14,201,368, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 200 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 200 mg/day (moderate-confidence extraction from PubMed abstracts).[1707,, etc.]
Clinical Depth
Humans: 49 • RCTs: 20 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 67 • Interactions: 47
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
129 total studies · 8 recent
Timeline
Animal-only studies
265
In vitro / tissue
174
Total indexed
129
Safety adverse signals
67
Human studies
49
Interaction signals
47
Weighted direction score: -2 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
265
In vitro / tissue
174
Total indexed
129
Safety adverse signals
67
Human studies
49
Interaction signals
47
Randomized trials
20
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 40014460 • 2025 Mar
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Neuropsychopharmacol Rep
Open PubMedPMID 39601362 • 2024 Dec
Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study.
J Int Soc Sports Nutr
Open PubMedPMID 40289957 • 2025 Mar 7
The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.
Benefit reports: 5
Adverse reports: 4
No-effect reports: 0
Mixed reports: 4
Unclear reports: 0
Signal confidence: 0.44
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 7 mentions (confidence 0.44) across Supplements, Biohackers, HubermanLab.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
post • r/Supplements • benefit
Does Rhodiola Rosea really have a noticeable effect on someone? I really tried to make it effective. Wanted to use it for wakefulness, mood, focus, energy: for studying and working on boring stuff on paper or computer. I tried 300mg Rhodio…
Open mentionpost • r/Supplements • mixed
Seeking Advice on My Nootropic Stack: Methylene Blue, Noopept, Alpha-GPC, L-Theanine, Ashwagandha, Creatine, Rhodiola Rosea Hey everyone, I’ve been researching nootropics and have put together a stack that I’m considering for cognitive enh…
Open mentionpost • r/Biohackers • mixed
Subject: Seeking Advice on My Nootropic Stack: Methylene Blue, Noopept, Alpha-GPC, L-Theanine, Ashwagandha, Creatine, Rhodiola Rosea Hey everyone, I’ve been researching nootropics and have put together a stack that I’m considering for cogn…
amazon
Amazon search for Rhodiola Rosea
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 49, RCTs 20, meta-analyses 1.[1707,3953,4907, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40014460 from Neuropsychopharmacol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,, etc.]
Nutrients
PMID 41374026 • 2025 Nov 28
Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
Nutrients
Open PubMedPMID 38213037 • 2024
Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
J Diet Suppl
Open PubMedPMID 40005009 • 2025 Feb 14
Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players.
Nutrients
Open PubMedPMID 40873122 • 2025 Nov
Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study.
Ophthalmic Physiol Opt
Open PubMedPMID 37641937 • 2024 Feb 14
Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature.
Br J Nutr
Open PubMedPMID 37495266 • 2023 Oct
Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials.
Phytother Res
Open PubMedPMID 16948486 • 2006 Jun
Does Rhodiola rosea possess ergogenic properties?
Int J Sport Nutr Exerc Metab
Open PubMedPMID 33650944 • 2022 Aug
Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials.
Nutr Neurosci
Open PubMedterminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 200 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
post • r/Biohackers • benefit
Lifting the brain fog - a (successful) story. Hey all, wanted to share with you a journey that seems to have finally succeeded so hopefully someone else will get to enjoy better quality of life as well. I'm a 40 years old male who has seen…
Open mentionpost • r/Biohackers • unclear
Best supplements for sex drive. Leave a comment below for your suggestions and why. Also has anyone taking rhodiola rosea what’s a good dose for men thanks.
Open mentionpost • r/Biohackers • benefit
What has given you the biggest boost in energy/mental clarity? I've been struggling with just feeling so exhausted and sluggish all the time. My health is fair- I eat pretty clean, get a good amount of protein, stay pretty active, prioriti…
Open mentionpost • r/HubermanLab • mixed
Ive been diagnosed with genralized anxiety disorder (GAD) and my stress is too high. What worked the best for you and how did you return to normal? My background: 28M, unemployed, job searching lead to GAD. Supplement stack : Before sleep,…
Open mentionpost • r/Supplements • mixed
Supplements high cortisol, depression and anxiety For 8 months I’m stuck in fight/flight after my miscarriage and iron dificiency (which is resolved). I became very anxious and depressed. I’ve tried so many things: iron infusion, good diet…
Open mentionCommunity Sources
PUBMED • 2024 • Human evidence curation set
PMID 39601362 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40289957 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41374026 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38213037 from J Diet Suppl.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40005009 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40873122 from Ophthalmic Physiol Opt.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37641937 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37495266 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16948486 from Int J Sport Nutr Exerc Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33650944 from Nutr Neurosci.
Outcome: See linked PubMed abstract for methods and outcomes.[1707,3953,4907, etc.]
Open source