Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[1405,1844,2597, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
94/100
High depth from human/RCT/meta counts
Community Direction
-20
Caution Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 3 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[621,764,1000, etc.]
Dose guide: Human-study daily dose: 320 mg/day (moderate-confidence extraction from PubMed abstracts)..[621,764,1000, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 320 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 320 mg/day (moderate-confidence extraction from PubMed abstracts).[,, etc.]
Clinical Depth
Humans: 86 • RCTs: 14 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 85 • Interactions: 42
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
126 total studies · 2 recent
Timeline
Total indexed
126
Human studies
86
Safety adverse signals
85
In vitro / tissue
63
Interaction signals
42
Animal-only studies
41
Weighted direction score: -20 (Caution Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
126
Human studies
86
Safety adverse signals
85
In vitro / tissue
63
Interaction signals
42
Animal-only studies
41
Randomized trials
14
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 32620155 • 2020 Jul 3
A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency.
BMC Urol
Open PubMedPMID 39042923 • 2025 Sep
Beneficial effects of saw palmetto (Serenoa repens) fruit extract on the urinary symptoms of healthy Japanese adults with possible lower urinary tract symptoms: A randomized, double-blind, placebo-controlled study.
Nutr Health
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
aggregate • unclear
Aggregate community signal: 3 directional mentions (benefit 1, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Saw Palmetto
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 86, RCTs 14, meta-analyses 0.[1405,1844,2597, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32620155 from BMC Urol.
Outcome: See linked PubMed abstract for methods and outcomes.
PMID 35334848 • 2022 Mar 11
Beneficial Effects of Saw Palmetto Fruit Extract on Urinary Symptoms in Japanese Female Subjects by a Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
Nutrients
PMID 26891611 • 2016 Jun
Saw Palmetto for Symptom Management During Radiation Therapy for Prostate Cancer.
J Pain Symptom Manage
Open PubMedPMID 11170151 • 2001 Feb 15
Do saw palmetto extracts block human alpha1-adrenoceptor subtypes in vivo?
Prostate
Open PubMedPMID 18534327 • 2008 Jun
A detailed safety assessment of a saw palmetto extract.
Complement Ther Med
Open PubMedPMID 33003518 • 2020 Sep 29
Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.
Nutrients
Open PubMedPMID 37327163 • 2023 Jun
Benign Prostatic Hyperplasia: Rapid Evidence Review.
Am Fam Physician
Open PubMedPMID 40627570 • 2025 Jul 1
Addressing the Root Causes of Female Hair Loss and Non-Pharmaceutical Interventions.
J Drugs Dermatol
Open PubMedPMID 31451276 • 2019 Oct
Benign prostate hyperplasia and nutrition.
Clin Nutr ESPEN
Open PubMedPMID 35428430 • 2022 May
Nutraceuticals and Phytotherapy in Men's Health: Antioxidants, Pro-oxidants, and a Novel Opportunity for Lifestyle Changes.
Urol Clin North Am
Open PubMedSearch fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22saw%20palmetto%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22saw%20palmetto%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=saw%20palmetto
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 320 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$14.00.
Legacy community note: Popular among men over 40 for prostate health. Some report improved urinary symptoms, others see no change. Hair loss community interested but evidence less strong. Low risk makes it worth trying for many.
Community Sources
PUBMED • 2025 • Human evidence curation set
PMID 39042923 from Nutr Health.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35334848 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26891611 from J Pain Symptom Manage.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11170151 from Prostate.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18534327 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33003518 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37327163 from Am Fam Physician.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40627570 from J Drugs Dermatol.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31451276 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35428430 from Urol Clin North Am.
Outcome: See linked PubMed abstract for methods and outcomes.[1405,1844,2597, etc.]
Open source