Implementation Blueprint
Goal alignment: Longevity, Detox Support, Metabolic Health.[36,93,409, etc.]
Dose guide: 10-40 mg active sulforaphane/day.[36,93,409, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
10-40 mg active sulforaphane/day
Supplement
Activates NRF2-linked antioxidant response elements.[2108,3319,3345, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
53
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 7 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Detox Support, Metabolic Health.[36,93,409, etc.]
Dose guide: 10-40 mg active sulforaphane/day.[36,93,409, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
10-40 mg active sulforaphane/day
Clinical Depth
Humans: 237 • RCTs: 25 • Meta: 4
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 397 • Interactions: 279
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
409 total studies · 4 recent
Timeline
In vitro / tissue
838
Animal-only studies
810
Total indexed
409
Safety adverse signals
397
Interaction signals
279
Human studies
237
Weighted direction score: 53 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
838
Animal-only studies
810
Total indexed
409
Safety adverse signals
397
Interaction signals
279
Human studies
237
Randomized trials
25
Meta-analyses
4
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35246237 • 2022 Mar 4
Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis.
Mol Autism
Open PubMedPMID 37023957 • 2023 Jun 1
Sulforaphane exhibits potent renoprotective effects in preclinical models of kidney diseases: A systematic review and meta-analysis.
Life Sci
Open PubMedPMID 41275316 • 2025 Nov 22
Investigating the clinical efficacy, safety and molecular mechanism of sulforaphane in autism spectrum disorder: an integrated study combining meta-analysis, network pharmacology, and computational biology.
Benefit reports: 5
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.29
Benefits
Adverse
No Effect
Users care strongly about active vs precursor dose transparency. | Step2: Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 3 mentions (confidence 0.29) across Biohackers, ketoscience, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
post • r/Biohackers • benefit
[EU/FR] The "Hard Detox" Budget Stack: 3g NAC + Activated Sulforaphane for <€20/mo (Protocol) Hi everyone, I’ve been refining a "Phase II" liver detox and longevity stack for a while. My goal was to hit clinical dosages (e.g., 3g daily NAC…
Open mentionpost • r/Biohackers • benefit
Best way to make sulforaphane supplements? Hey squad, I've been making some sulforaphane supplements at home from broccoli sprouts and ground mustard seed so there's myrosinase to convert glucoraphanin into sulforaphane. I've done two batc…
Open mentionpost • r/ketoscience • unclear
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders (2025)
amazon
Amazon search for Sulforaphane (broccoli sprout extract)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
RCT • 2021 • Adults
Small human intervention studies.
Outcome: Increases phase II detox marker activity.[2108,3319,3345, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 237, RCTs 25, meta-analyses 4.[2108,3319,3345, etc.]
Open sourceBMC Pharmacol Toxicol
PMID 31280187 • 2019 Jul-Aug
Chemoprevention of Breast Cancer With Vitamins and Micronutrients: A Concise Review.
In Vivo
Open PubMedPMID 40041932 • 2025 Jun 2
Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer.
Cancer Prev Res (Phila)
Open PubMedPMID 31155953 • 2020
Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.
Nutr Cancer
Open PubMedPMID 36014767 • 2022 Aug 10
Accumulation of Sulforaphane and Alliin in Human Prostate Tissue.
Nutrients
Open PubMedPMID 33503851 • 2021 Jan 25
Brain Training and Sulforaphane Intake Interventions Separately Improve Cognitive Performance in Healthy Older Adults, Whereas a Combination of These Interventions Does Not Have More Beneficial Effects: Evidence from a Randomized Controlled Trial.
Nutrients
Open PubMedPMID 22537070 • 2012 Nov
Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
Int J Food Sci Nutr
Open PubMedPMID 37619675 • 2024 Jan
Sulforaphane Supplementation Did Not Modulate NRF2 and NF-kB mRNA Expressions in Hemodialysis Patients.
J Ren Nutr
Open PubMedPMID 35934064 • 2022 Nov
Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms.
Gastroenterology
Open PubMedPMID 33207780 • 2020 Nov 16
Efficacy of Sulforaphane in Neurodegenerative Diseases.
Int J Mol Sci
Open PubMedPMID 33003518 • 2020 Sep 29
Dietary Factors and Supplements Influencing Prostate Specific-Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials.
Nutrients
Open PubMedPMID 36915952 • 2023
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions.
CNS Neurol Disord Drug Targets
Open PubMedPMID 38612798 • 2024 Apr 3
Do Brassica Vegetables Affect Thyroid Function?-A Comprehensive Systematic Review.
Int J Mol Sci
Open PubMedPerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$22.00.
Legacy community note: Rapidly growing appreciation. Dr. Rhonda Patrick has popularized sulforaphane extensively. Growing broccoli sprouts at home is popular in health community. Supplement standardization is improving.
post • r/Supplements • unclear
Reminder that you need fruits and veggies daily to get flavonoids that prevent cancer, diabetes, cardiovascular disease, etc. — because there are thousands of them in a fruit It is not wise to choose flavonoid supplements or “extracted” po…
Open mentionpost • r/Supplements • unclear
Bryan Johnson's Supplement Lis # Bryan Johnson's Supplement List I just finished a writeup on Bryan Johnson's Supplement stack and figured I would share here for anyone interested. [**This full list with more information**](https://jakesjo…
Open mentionpost • r/Biohackers • unclear
anyone got any tips on how to eat broccoli sprouts without throwing up About a year ago I bought broccoli seeds and mustard seeds to ground up and mix with the spouts for the sulforaphane, but I wasn't prepared for how much i would hate th…
Open mentionpost • r/Biohackers • unclear
Sulforaphane? Anyone here taking this as a supplement or in food form ? Opinions?
Open mentioncomment • r/Biohackers • unclear
Ask it if combining sulforaphane and NAC cancel each other out
Open mentioncomment • r/ketoscience • benefit
# Abstract The brain accounts for about 2% of the body’s weight, but it consumes about 20% of the body’s energy at rest, primarily derived from ATP produced in mitochondria. The brain thus has a high mitochondrial density in its neurons be…
Open mentionCommunity Sources
PUBMED • 2022 • Human evidence curation set
PMID 35246237 from Mol Autism.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37023957 from Life Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41275316 from BMC Pharmacol Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31280187 from In Vivo.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40041932 from Cancer Prev Res (Phila).
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31155953 from Nutr Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36014767 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33503851 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22537070 from Int J Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37619675 from J Ren Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35934064 from Gastroenterology.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33207780 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33003518 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36915952 from CNS Neurol Disord Drug Targets.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38612798 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2108,3319,3345, etc.]
Open source