Supplement
Supports broad cellular function with category-specific mechanisms.[1375,1754,2980, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
53
Positive Lean • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 13 • mentions 7 • links 24
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[267,294,334, etc.]
Dose guide: Human-study daily dose: 450 mg-770 mg/day (moderate-confidence extraction from PubMed abstracts)..[267,294,334, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 450 mg-770 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 450 mg-770 mg/day (moderate-confidence extraction from PubMed abstracts).[1375,, etc.]
Clinical Depth
Humans: 44 • RCTs: 11 • Meta: 3
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 79 • Interactions: 34
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
86 total studies · 2 recent
Timeline
Animal-only studies
170
In vitro / tissue
91
Total indexed
86
Safety adverse signals
79
Human studies
44
Interaction signals
34
Weighted direction score: 53 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
170
In vitro / tissue
91
Total indexed
86
Safety adverse signals
79
Human studies
44
Interaction signals
34
Randomized trials
11
Meta-analyses
3
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 37686709 • 2023 Aug 22
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use.
Nutrients
Open PubMedPMID 29633089 • 2018 Apr
Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis.
Drugs
Open PubMedPMID 40360723 • 2026 Jan
Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.
Int J Impot Res
Benefit reports: 5
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.41
Benefits
Adverse
No Effect
Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 6 mentions (confidence 0.41) across Supplements, Biohackers, HubermanLab.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
post • r/Supplements • benefit
Severe Erectile Dysfunction Hi everyone please help, I just turned 30/male and for many years now I just can’t get my member up. I’ve done all the tests and I’m generally healthy, active, and very engaged in fitness. I’ve been experimentin…
Open mentionpost • r/Supplements • mixed
Prone Masturbation destroyed my life... need serious help please I was minding my own business one day when I suddenly noticed something strange happening in my body. My pelvic area began to feel desensitized. I sensed that something was w…
Open mentionpost • r/Supplements • benefit
Is there a definitive list of supplements that are associated with improved male sexual function and libido? 34 year old dude here. I’ve been struggling with ED for a few years now. Lately it’s been getting to me much more than I anticipat…
amazon
Amazon search for Tribulus Terrestris
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 44, RCTs 11, meta-analyses 3.[1375,1754,2980, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37686709 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
PMID 34836225 • 2021 Nov 7
The Effects of 6 Weeks of Tribulus terrestris L. Supplementation on Body Composition, Hormonal Response, Perceived Exertion, and CrossFit(®) Performance: A Randomized, Single-Blind, Placebo-Controlled Study.
Nutrients
Open PubMedPMID 36498228 • 2022 Dec 2
6-Week Supplementation with Tribulus terrestris L. to Trained Male CrossFit(®) Athletes on Muscle, Inflammation, and Antioxidant Biomarkers: A Randomized, Single-Blind, Placebo-Controlled Trial.
Int J Environ Res Public Health
Open PubMedPMID 36073362 • 2023
Effect of Tribulus terrestris L. supplementation on Exercise-Induced Oxidative Stress and Delayed Onset Muscle Soreness Markers: A Pilot Study.
J Diet Suppl
Open PubMedPMID 10861339 • 2000 Jun
The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males.
Int J Sport Nutr Exerc Metab
Open PubMedPMID 32375572 • 2021 Sep
Tribulus Terrestris may decrease muscle damage markers following a high-intensity resistance exercise: A pilot study.
Int J Vitam Nutr Res
Open PubMedPMID 17530942 • 2007 May
The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.
J Strength Cond Res
Open PubMedPMID 29568244 • 2018
Herbal medicine for sports: a review.
J Int Soc Sports Nutr
Open PubMedPMID 32408715 • 2020 May 12
A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L.
Biomolecules
Open PubMedPMID 37697053 • 2024 Jun
Do "testosterone boosters" really increase serum total testosterone? A systematic review.
Int J Impot Res
Open PubMedPMID 30604177 • 2019 Dec
Supplements with purported effects on muscle mass and strength.
Eur J Nutr
Open PubMedterminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 450 mg-770 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 3 PubMed studies (mg/day).
post • r/Supplements • unclear
Any experience with tribulus terrestris? Just curious,if there is any real effect on it?
Open mentionpost • r/Biohackers • benefit
6-Keto plant based annabolic review Ok so i started taking 6-keto (wont name the product which has 6-keto or this post gets banned) with Tribulus Terrestris to increase my testosterone and i can confirm it 100% works on me. I have been usi…
Open mentionpost • r/HubermanLab • benefit
Prodcast Roundup 2/2 - 2/24 **Longevity. Strength. Love. Agency.** This week’s episodes spanned brain aging, performance optimization, genetic influence, and relationship science. Below is the full breakdown — categorized, linked, and dist…
Open mentionpost • r/Supplements • unclear
Is Maca Peruana + Tribulus Terrestris + Muira Puama an overkill? So i wanted to try a few supplements for improving libido. From what i read Maca and Tribulus are the go-to supplements in this case. However, i was reading that Muira Puama,…
Open mentionpost • r/Supplements • benefit
Hey.I just bought some tribulus terrestris tea .Hoping some test boost Been advised to give it a try...I bought tribulus terrestris tea (Bulgarian one) Today was the first day I tried.Just one tea.(Instead of 2-3 ,which is the recommendati…
Open mentionCommunity Sources
PUBMED • 2018 • Human evidence curation set
PMID 29633089 from Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 40360723 from Int J Impot Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34836225 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36498228 from Int J Environ Res Public Health.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36073362 from J Diet Suppl.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2000 • Human evidence curation set
PMID 10861339 from Int J Sport Nutr Exerc Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32375572 from Int J Vitam Nutr Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17530942 from J Strength Cond Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29568244 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32408715 from Biomolecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37697053 from Int J Impot Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30604177 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1375,1754,2980, etc.]
Open source